Abstract
Synthetic analogues of liposomes prepared from non-ionic surfactants, known as niosomes, have been used as vesicular drug carriers. Diclofenac sodium has been entrapped in niosomes comprising Tween 85 and Tween 85- poloxamer F 108 mixture. Anti-inflammatory efficacy of these niosomes were compared with that of free diclofenac sodium in adjuvant induced arthritic rats. It was found that the niosomal diclofenac sodium formulations prepared by employing a 1:1 combination of Tween 85 and poloxamer F 108 elicits a better and consistent anti-inflammatory activity for more than 72 hours after administration of a single dose.
| Original language | English |
|---|---|
| Pages (from-to) | 46-48 |
| Number of pages | 3 |
| Journal | Indian Journal of Pharmacology |
| Volume | 26 |
| Issue number | 1 |
| Publication status | Published - 1994 |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)