TY - JOUR
T1 - Anti-inflammatory and Antinociceptive Activities of "Coccinia indica W. &A." Fruit Juice Powder in Animals
AU - Rao, G.M.M.
AU - Rao, Ch.V.
AU - Sudhakara, M.
AU - Pandey, M.M.
AU - Rawat, A.K.S.
AU - Sirwaikar, A.
AU - Joshi, A.B.
N1 - Cited By :7
Export Date: 10 November 2017
CODEN: NPSCF
Correspondence Address: Rao, G.M.M.; Pharmacog./Ethnopharmacology Div., Natl. Botanical Research Institute, Lucknow, India; email: [email protected]
Chemicals/CAS: acetic acid, 127-08-2, 127-09-3, 64-19-7, 71-50-1; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; histamine, 51-45-6, 56-92-8, 93443-21-1; ibuprofen, 15687-27-1
References: Alcaraz, M.J., Jimenez, M.J., Flavonoids as an antiinflammatory agents (1988) Fitoterapia, 59, pp. 25-38; Castro, J., Saseme, H., Sussman, H., Bullette, P., Diverse effect of SKF 52 and antioxidants on CCl4 induced changes in liver microsomal P-450 content and ethylmorphine metabolism (1968) Life. Sci., 7, pp. 129-136; Chawla, A.S., Singh, M., Murthy, M.S., Gupta, M.P., Singh, H., Anti-inflammatory action of ferulic acid and its esters in carrageenan induced rat paw oedema model (1987) Ind. J. Exp. Biol., 25, pp. 187-189; Della, L.A., Tubaro, A., Dri, P., Zilli, C., Del, N.P., The role of flavonoids in the antiinflammatory activity of chamomilla recutita (1968) Clin. Biol. Res., 213, pp. 481-486; Di Rosa, M., Biological properties of carrageenan (1972) J. Pharm. Pharmacol., 24, pp. 89-102; Kirtikar, K.R., Basu, B.D., (1933) Indian Medicinal Plants, 2, pp. 1151-1152. , Lalit Mohan Basu, Allhabad; Lino, C.S., Taveira, M.L., Viana, G.S.B., Matos, F.J.A., Analgesic and antiinflammatory activity of Justicia pectoralis Jacq and its main constituents: Coumarin & Umbelliferone (1997) Phytother. Res., 11, pp. 211-215; Miller, L.C., Tainter, M.L., Evaluation of ED50 and its error by means of logarithmic probit graph papers (1944) Proc. Soc. Exp. Biol. Med., 57, pp. 261-264; Nadkarni, A.K., (1954) Indian Materia Medica, 1, p. 300. , popular Book Depot, Bombay-1; Parmar, N.S., Ghosh, M.N., Antiinflammatory activity of Gossypin a bioflavonoid isolated from Hibiscus vitifolius Linn, Indian (1978) J. Pharmacol., 10, pp. 277-293; Pillai, N.R., Ghosh, D., Uma, R., Kumar, A., (1980) Bull. Med. Ethnobot. Res., 1, p. 234; Shaw, B.P., Gupta, S., (1981) Nagarjun, 25, p. 24; Spadaro, Evidence of correlation between mast-cell Histamine and Beta-Endorphin from Nil Pitutary in the Homoeostasis (1987) Pharmacol. Res. Commn., 19, pp. 131-136; Winter, C.A., Risley, E.A., Nuss, G.W., Carrageenin induced edema in hind paw of the rats as an assay for anti-inflammatory drugs (1962) Proc. Soc. Exp. Biol. Med., 111, pp. 544-547; Witkin, L.B., Huebner, C.F., Galdi, F., Okeefe, E., Spitaletta, P., Plummer, A.J., Pharmacognosy of 2 amino-indane hydrochloride (Su 8629): A potent non-narcotic analgesic (1961) J. Pharmacol. Exp. Therape., 133, pp. 400-408
PY - 2004
Y1 - 2004
N2 - The fresh fruit juice powder of Coccinia indica W.&A., (Cucurbitaceae, CJP) was studied for the possible activities of antiinflammatory and antinociceptive to rationalize the folkloric use of the plant juice as rasayana. CJP at the doses of 50-200 mg/kg caused a significant (P<0.05 to P<0.001) inhibition of paw edema induced by λ carrageenin (1%) and histamine (10-3 g/ml, 0.1 ml) in rats. The effect was comparable to the standard cycloxygenase inhibitor brufen at 100 mg/kg and protective percentages were 63.41% and 65.78% respectively. Administration of CJP (50-200 mg/kg) exhibited a moderate increase of the pain threshold on analgesy-meter induced mechanical pain. However CJP significantly prevented the writhing induced by acetic acid in mice and the percentages of inhibitions were 16.98%-35.47%, which is equivalent to 36.67% produced by brufen. These data indicate that the fruit juice of Coccinia indica rationalizes the traditional system of medicine.
AB - The fresh fruit juice powder of Coccinia indica W.&A., (Cucurbitaceae, CJP) was studied for the possible activities of antiinflammatory and antinociceptive to rationalize the folkloric use of the plant juice as rasayana. CJP at the doses of 50-200 mg/kg caused a significant (P<0.05 to P<0.001) inhibition of paw edema induced by λ carrageenin (1%) and histamine (10-3 g/ml, 0.1 ml) in rats. The effect was comparable to the standard cycloxygenase inhibitor brufen at 100 mg/kg and protective percentages were 63.41% and 65.78% respectively. Administration of CJP (50-200 mg/kg) exhibited a moderate increase of the pain threshold on analgesy-meter induced mechanical pain. However CJP significantly prevented the writhing induced by acetic acid in mice and the percentages of inhibitions were 16.98%-35.47%, which is equivalent to 36.67% produced by brufen. These data indicate that the fruit juice of Coccinia indica rationalizes the traditional system of medicine.
M3 - Article
SN - 1226-3907
VL - 10
SP - 20
EP - 23
JO - Natural Product Sciences
JF - Natural Product Sciences
IS - 1
ER -