The fresh juice of the indigenous drug A. vera (0.2 ml/100 g, i.p.) was studied for its antiinflammatory and wound healing properties in rats. Anti-inflammatory action was studied by observing percent reduction in carrageenin-induced paw oedema at 3 h. Wound healing effects were studied on incision (skin breaking strength), excision (percent wound contraction and epithelisation time) and dead space (granuloma breaking strength and biochemical parameters) wound models. A. vera showed significant anti-inflammatory activity in acute inflammatory model without any significant effect on chronic inflammation. Significant increase in breaking strength (skin and granuloma tissue), enhanced wound contraction and decreased epithelisation period were observed. An increase in lysyl oxidase activity and mucopolysaccharide content were also seen. This drug could therefore increase tensile strength by increasing cross-linking in collagen and interactions with the ground substance.
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|Published - 01-01-1994
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