TY - JOUR
T1 - Anti-neoplastic activity of Anisochilus cornosus (L.f) wall on HeLa cell line
AU - Bhagath, Jay Kumar
AU - Lobo, Richard
AU - Ballal, Mamatha
AU - Polu, Picheswara Rao
PY - 2016
Y1 - 2016
N2 - Anisochilus carnosus (L.f.) wall is an annual herb belonging to the family Lamiaceae which grows on rocks. It is used traditionally for the treatment of gastric ulcers, skin infections, cough, cold, digestion and eczema. Plant was collected and extracted with petroleum ether, ethanol and water separately and all the three obtained extracts were screened for in vitro anticancer activity against human cervical carcinoma cell lines (HeLa) by using MTT and SRB assays. Cytotoxic potential showed by Petroleum ether and ethanolic extracts with an IC50 of 5.88μg/ml and 78.73μg/ml respectively when compared with Doxorubicin with IC50 of 1.86μg/ml in MTT assay. and IC50 of 17.93 μg/ml and 87.24 μg/ml respectively by SRB assay. Even though the cytotoxic activity shown by both petroleum ether and ethanolic extracts the possible mechanism for its cytotoxicity is not clear. Hence mechanistic evaluation of both plant extracts is needed in future research, so that we could come out with potent and selective anticancer agents derived from plant source.
AB - Anisochilus carnosus (L.f.) wall is an annual herb belonging to the family Lamiaceae which grows on rocks. It is used traditionally for the treatment of gastric ulcers, skin infections, cough, cold, digestion and eczema. Plant was collected and extracted with petroleum ether, ethanol and water separately and all the three obtained extracts were screened for in vitro anticancer activity against human cervical carcinoma cell lines (HeLa) by using MTT and SRB assays. Cytotoxic potential showed by Petroleum ether and ethanolic extracts with an IC50 of 5.88μg/ml and 78.73μg/ml respectively when compared with Doxorubicin with IC50 of 1.86μg/ml in MTT assay. and IC50 of 17.93 μg/ml and 87.24 μg/ml respectively by SRB assay. Even though the cytotoxic activity shown by both petroleum ether and ethanolic extracts the possible mechanism for its cytotoxicity is not clear. Hence mechanistic evaluation of both plant extracts is needed in future research, so that we could come out with potent and selective anticancer agents derived from plant source.
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M3 - Article
AN - SCOPUS:84964053651
SN - 0975-5071
VL - 8
SP - 186
EP - 190
JO - Der Pharmacia Lettre
JF - Der Pharmacia Lettre
IS - 4
ER -