TY - JOUR
T1 - Anti-Prolactin and Antigrowth Hormone Effects on Oxidative Stress and Physiological Parameters in MNU Induced Mammary Tumor in Sprague Dawley Rat
AU - Kour, Maninder
AU - Bhat, Kumar M.
AU - Vinodini, N. A.
AU - Sreeram, Saraswathy
AU - Rao, Durga
N1 - Funding Information:
Funding – The project was done under Manipal University full time PhD scholarship scheme.
Publisher Copyright:
© 2021, Journal of International Dental and Medical Research. All Rights Reserved.
PY - 2021
Y1 - 2021
N2 - Breast cancer is the most common cancer diagnosed in women, accounting for more than 1 in 10 new cancer diagnosed and second most common cause of death among women. This study was intended to assess the effect of cabergoline and octreotide in tumorigenesis and progression prior to and post tumor induction in Sprague Dawley rats. 30 day old inbred SD female rats of body weight (70-80 grams) were taken for this study and N-Methyl-Nitroso-Urea was used for mammary tumor induction. The rats were pre inhibited with cabergoline & octreotide alone and in combination followed by MNU and post treated group ( MNU followed by drugs) were studied. The parameters such as tissue glutathione, malondialdehyde and physiological parameters like tumor weight, tumor occurrence, volume were measured. The Pre treated combination group showed a significant decrease in mean body weight tumor weight, tumor volume, tumor latency, tumor incidence rate compared to post inhibited group. A near normal levels of tissue GSH, and a decrease levels in MDA was observed in pre-inhibited combination group compared to post hormone inhibited group. The results suggest that pretreatment with combination of cabergoline and octreotide is a better therapeutic measure than single drug alone for inhibition of tumorgenesis
AB - Breast cancer is the most common cancer diagnosed in women, accounting for more than 1 in 10 new cancer diagnosed and second most common cause of death among women. This study was intended to assess the effect of cabergoline and octreotide in tumorigenesis and progression prior to and post tumor induction in Sprague Dawley rats. 30 day old inbred SD female rats of body weight (70-80 grams) were taken for this study and N-Methyl-Nitroso-Urea was used for mammary tumor induction. The rats were pre inhibited with cabergoline & octreotide alone and in combination followed by MNU and post treated group ( MNU followed by drugs) were studied. The parameters such as tissue glutathione, malondialdehyde and physiological parameters like tumor weight, tumor occurrence, volume were measured. The Pre treated combination group showed a significant decrease in mean body weight tumor weight, tumor volume, tumor latency, tumor incidence rate compared to post inhibited group. A near normal levels of tissue GSH, and a decrease levels in MDA was observed in pre-inhibited combination group compared to post hormone inhibited group. The results suggest that pretreatment with combination of cabergoline and octreotide is a better therapeutic measure than single drug alone for inhibition of tumorgenesis
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M3 - Article
AN - SCOPUS:85116884708
SN - 1309-100X
VL - 14
SP - 1190
EP - 1195
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 3
ER -