Anti-Prolactin and Antigrowth Hormone Effects on Oxidative Stress and Physiological Parameters in MNU Induced Mammary Tumor in Sprague Dawley Rat

Breast cancer is the most common cancer diagnosed in women, accounting for more than 1 in 10 new cancer diagnosed and second most common cause of death among women. This study was intended to assess the effect of cabergoline and octreotide in tumorigenesis and progression prior to and post tumor induction in Sprague Dawley rats. 30 day old inbred SD female rats of body weight (70-80 grams) were taken for this study and N-Methyl-Nitroso-Urea was used for mammary tumor induction. The rats were pre inhibited with cabergoline & octreotide alone and in combination followed by MNU and post treated group ( MNU followed by drugs) were studied. The parameters such as tissue glutathione, malondialdehyde and physiological parameters like tumor weight, tumor occurrence, volume were measured. The Pre treated combination group showed a significant decrease in mean body weight tumor weight, tumor volume, tumor latency, tumor incidence rate compared to post inhibited group. A near normal levels of tissue GSH, and a decrease levels in MDA was observed in pre-inhibited combination group compared to post hormone inhibited group. The results suggest that pretreatment with combination of cabergoline and octreotide is a better therapeutic measure than single drug alone for inhibition of tumorgenesis