TY - JOUR
T1 - Antiallergic, antipyretic, hypoglycemic and hepatoprotective effects of aqueous extract of Coronopus didymus LINN
AU - Mantena, S.K.
AU - Mutalik, S.
AU - Srinivasa, H.
AU - Subramanian, G.S.
AU - Prabhakar, K.R.
AU - Reddy, K.R.
AU - Srinivasan, K.K.
AU - Unnikrishnan, M.K.
N1 - Cited By :17
Export Date: 10 November 2017
CODEN: BPBLE
Correspondence Address: Mantena, S.K.; Manipal College of Pharmaceutical Sciences, Manipal-576104, Karnataka, India; email: [email protected]
Chemicals/CAS: 1,1 diphenyl 2 picrylhydrazyl, 1898-66-4; glibenclamide, 10238-21-8; ketotifen fumarate, 34580-14-8; silymarin, 65666-07-1; superoxide, 11062-77-4; Analgesics, Non-Narcotic; Anti-Allergic Agents; Hypoglycemic Agents; Plant Extracts; Water, 7732-18-5
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PY - 2005
Y1 - 2005
N2 - The aqueous extract of whole plant of Coronopus didymus LINN (CD) [Family: Bracicacea] was screened for antiallergic, antipyretic and hepatoprotective effects in rats and hypoglycemic activity in mice. The extract showed significant antiallergic, antipyretic, hypoglycemic and hepatoprotective activity at 200 and 400 mg/kg doses on oral administration. Mechanistically, CD acts as an antioxidant as evidenced by its ability to scavenge DPPH and superoxide radicals. All the observed activities may be due to the presence of flavonoids, saponins and tannins as they are reported to possess a variety of biological activities. © 2005 Pharmaceutical Society of Japan.
AB - The aqueous extract of whole plant of Coronopus didymus LINN (CD) [Family: Bracicacea] was screened for antiallergic, antipyretic and hepatoprotective effects in rats and hypoglycemic activity in mice. The extract showed significant antiallergic, antipyretic, hypoglycemic and hepatoprotective activity at 200 and 400 mg/kg doses on oral administration. Mechanistically, CD acts as an antioxidant as evidenced by its ability to scavenge DPPH and superoxide radicals. All the observed activities may be due to the presence of flavonoids, saponins and tannins as they are reported to possess a variety of biological activities. © 2005 Pharmaceutical Society of Japan.
U2 - 10.1248/bpb.28.468
DO - 10.1248/bpb.28.468
M3 - Article
SN - 0918-6158
VL - 28
SP - 468
EP - 472
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
IS - 3
ER -