Abstract
Bcl-2, an antiapoptotic protein, is considered as a potential target in cancer treatment since its oncogenic potential has been proven and is well documented. Antisense technology and RNA interference (RNAi) have been used to reduce the expression of the Bcl-2 gene in many types of cancer cells and are effective as adjuvant therapy along with the chemotherapeutic agents. The lack of appropriate delivery systems is considered to be the main hurdle associated with the RNAi. In this review, we discuss the antiapoptotic Bcl-2 protein, its oncogenic potential, and various approaches utilized to target Bcl-2 including suitable delivery systems employed for successful delivery of siRNA.
| Original language | English |
|---|---|
| Pages (from-to) | 1212-1221 |
| Number of pages | 10 |
| Journal | Artificial Cells, Nanomedicine and Biotechnology |
| Volume | 44 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 03-07-2016 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Biotechnology
- Medicine (miscellaneous)
- Biomedical Engineering
- Pharmaceutical Science
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