TY - JOUR
T1 - Anticancerous and antioxidant properties of fabricated silver nanoparticles involving bio-organic framework using medicinal plant Blumea lacera
AU - Pandey, Pradeep Kumar
AU - Gangwar, Chinky
AU - Yaseen, Bushra
AU - Kumar, Indresh
AU - Nayak, Rashmi
AU - Kumar, Saurabh
AU - Naik, Radhey Mohan
AU - Banerjee, Monisha
AU - Sarkar, Joy
N1 - Funding Information:
The authors are highly grateful to the Head of Department (HoD), Department of Chemistry (DoC), University of Lucknow (UoL), Lucknow (UP), India, for providing basic infrastructure facilities, like UV–visible spectrophotometry and FT-IR spectroscopy for performing experimental work for my Ph.D. degree. The authors are also thankful to Vice-Chancellor Prof. Alok Kumar Rai of Lucknow University for partially assisting with funds through the Award of Chhatra Kalyan scholarship to PP funded by University of Lucknow, India. The authors are also grateful to the Advanced Materials Research Centre (AMRC), Kamand campus, IIT Mandi, H.P, the sophisticated analytical instrumentation facility (SAIF), All India Institute of Medical Science (AIIMS), New Delhi, and Birbal Sahni institute of Palaeosciences, Lucknow, UP, India, for providing X-ray diffraction, transmission electron microscopy and field emission scanning electron microscopy facilities, respectively. The authors are indebted to the Centre of Excellence scheme, Government of Uttar Pradesh, India, for cell culture facility in Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow.
Funding Information:
The authors are highly grateful to the Head of Department (HoD), Department of Chemistry (DoC), University of Lucknow (UoL), Lucknow (UP), India, for providing basic infrastructure facilities, like UV–visible spectrophotometry and FT-IR spectroscopy for performing experimental work for my Ph.D. degree. The authors are also thankful to Vice-Chancellor Prof. Alok Kumar Rai of Lucknow University for partially assisting with funds through the Award of Chhatra Kalyan scholarship to PP funded by University of Lucknow, India. The authors are also grateful to the Advanced Materials Research Centre (AMRC), Kamand campus, IIT Mandi, H.P, the sophisticated analytical instrumentation facility (SAIF), All India Institute of Medical Science (AIIMS), New Delhi, and Birbal Sahni institute of Palaeosciences, Lucknow, UP, India, for providing X-ray diffraction, transmission electron microscopy and field emission scanning electron microscopy facilities, respectively. The authors are indebted to the Centre of Excellence scheme, Government of Uttar Pradesh, India, for cell culture facility in Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow.
Publisher Copyright:
© 2023, Institute of Chemistry, Slovak Academy of Sciences.
PY - 2023/7
Y1 - 2023/7
N2 - Cancer is the second foremost cause of death worldwide, and despite modern medicine development, it is needed to develop new plant-based drugs. The current study is mainly focused on the estimation of anticancerous activity of silver nanoparticles (AgNPs) fabricated by a simple and eco-friendly green approach by using leaf extract of the medicinal plant Blumea lacera (B. lacera). The prepared AgNPs were characterized by using different analytical tools. UV–visible spectra were recorded, which exhibited a sharp surface plasmonic resonance (SPR) band at 430 nm and confirmed the formation of AgNPs. The spherical morphology of synthesized AgNPs was determined with the help of field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM), and the average particle size was calculated using TEM and found to be 12.52 nm. The Fourier transformed infrared (FT-IR) spectrum of AgNPs showed characteristic bands of functional groups present in the biomolecules adsorb onto AgNPs, acting as a stabilizing agent. The crystallite nature of AgNPs formed was confirmed by the powder X-ray diffraction (PXRD) technique. The anticancerous activity of synthesized AgNPs was investigated against adherent human lung carcinoma cell A549. The minimal inhibition concentration (IC50 or MIC) value was found to be ~ 20 μg/mL for human lung carcinoma cell A549, and the result so obtained suggests that synthesized AgNPs via B. lacera possess a good ability to be used as an eco-friendly anticancerous agent. Moreover, the synthesized AgNPs possess good antioxidant activity compared to B. lacera plant leaves. The minimal inhibition concentration (IC50) of ~ 6 μg/mL for synthesized AgNPs was found. Graphical abstract: [Figure not available: see fulltext.]
AB - Cancer is the second foremost cause of death worldwide, and despite modern medicine development, it is needed to develop new plant-based drugs. The current study is mainly focused on the estimation of anticancerous activity of silver nanoparticles (AgNPs) fabricated by a simple and eco-friendly green approach by using leaf extract of the medicinal plant Blumea lacera (B. lacera). The prepared AgNPs were characterized by using different analytical tools. UV–visible spectra were recorded, which exhibited a sharp surface plasmonic resonance (SPR) band at 430 nm and confirmed the formation of AgNPs. The spherical morphology of synthesized AgNPs was determined with the help of field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM), and the average particle size was calculated using TEM and found to be 12.52 nm. The Fourier transformed infrared (FT-IR) spectrum of AgNPs showed characteristic bands of functional groups present in the biomolecules adsorb onto AgNPs, acting as a stabilizing agent. The crystallite nature of AgNPs formed was confirmed by the powder X-ray diffraction (PXRD) technique. The anticancerous activity of synthesized AgNPs was investigated against adherent human lung carcinoma cell A549. The minimal inhibition concentration (IC50 or MIC) value was found to be ~ 20 μg/mL for human lung carcinoma cell A549, and the result so obtained suggests that synthesized AgNPs via B. lacera possess a good ability to be used as an eco-friendly anticancerous agent. Moreover, the synthesized AgNPs possess good antioxidant activity compared to B. lacera plant leaves. The minimal inhibition concentration (IC50) of ~ 6 μg/mL for synthesized AgNPs was found. Graphical abstract: [Figure not available: see fulltext.]
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U2 - 10.1007/s11696-023-02723-5
DO - 10.1007/s11696-023-02723-5
M3 - Article
AN - SCOPUS:85148518308
SN - 0366-6352
VL - 77
SP - 3603
EP - 3617
JO - Chemical Papers
JF - Chemical Papers
IS - 7
ER -
