TY - JOUR
T1 - Anticonvulsant and neurotoxicity profile of Nardostachys jatamansi in rats
AU - Rao, Vidya S.
AU - Rao, Anjali
AU - Karanth, K. Sudhakar
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Ethanol extract of the roots of Nardostachys jatamansi DC. (Valerianaceae) was studied for its anticonvulsant activity and neurotoxicity, alone and in combination with phenytoin in rats. The results demonstrated a significant increase in the seizure threshold by Nardostachys jatamansi root extract against maximal electroshock seizure (MES) model as indicated by a decrease in the extension/flexion (E/F) ratio. However, the extract was ineffective against pentylenetetrazole (PTZ)-induced seizures. Nardostachys jatamansi root extract also showed minimal neurotoxicity against rotarod test at doses that increased the seizure threshold. Further, pretreatment of rats with phenytoin at a dose of 12.5, 25, 50 and 75 mg/kg in combination with 50 mg/kg of Nardostachys jatamansi root extract resulted in a significant increase in the protective index (PI) of phenytoin from 3.63 to 13.18. The dose response studies of phenytoin alone and in combination with Nardostachys jatamansi extract on the serum levels of phenytoin clearly demonstrated the synergistic action of both the drugs.
AB - Ethanol extract of the roots of Nardostachys jatamansi DC. (Valerianaceae) was studied for its anticonvulsant activity and neurotoxicity, alone and in combination with phenytoin in rats. The results demonstrated a significant increase in the seizure threshold by Nardostachys jatamansi root extract against maximal electroshock seizure (MES) model as indicated by a decrease in the extension/flexion (E/F) ratio. However, the extract was ineffective against pentylenetetrazole (PTZ)-induced seizures. Nardostachys jatamansi root extract also showed minimal neurotoxicity against rotarod test at doses that increased the seizure threshold. Further, pretreatment of rats with phenytoin at a dose of 12.5, 25, 50 and 75 mg/kg in combination with 50 mg/kg of Nardostachys jatamansi root extract resulted in a significant increase in the protective index (PI) of phenytoin from 3.63 to 13.18. The dose response studies of phenytoin alone and in combination with Nardostachys jatamansi extract on the serum levels of phenytoin clearly demonstrated the synergistic action of both the drugs.
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U2 - 10.1016/j.jep.2005.06.031
DO - 10.1016/j.jep.2005.06.031
M3 - Article
C2 - 16095854
AN - SCOPUS:27644554506
SN - 0378-8741
VL - 102
SP - 351
EP - 356
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 3
ER -