@article{9010bfc2f22e41e598f1fdd1c3c964e0,
title = "Antidiabetic activity of alcohol root extract of Holostemma annulare in NIDDM rats",
abstract = "The antidiabetic potential of the alcohol root extract of Holostemma annulare Schum. (Asclepiadaceae), a medicinal plant widely used in more than 34 Ayurvedic preparations, was evaluated in the streptozotocin-nicotinamide-induced type 2 diabetic model. Graded doses of the alcohol root extract were administered to normal and experimental diabetic rats for 15 days. A significant (p <0.05) reduction was observed in the fasting blood glucose levels of normal as well as diabetic rats. Serum insulin levels were stimulated in the diabetic animals treated with the extract. Body weight, serum lipid profiles, serum urea and creatinine levels were estimated in extract-treated normal and diabetic rats. In addition, glycosylated hemoglobin and liver glycogen levels assessed in the extract-treated diabetic rats were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the treatment of diabetes mellitus. {\textcopyright} 2007 Informa Healthcare.",
author = "A. Shirwaikar and I.S.R. Punitha and M. Upadhye and A. Dhiman",
note = "Cited By :4 Export Date: 10 November 2017 CODEN: PHBIF Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: creatinine, 19230-81-0, 60-27-5; glucose, 50-99-7, 84778-64-3; glycogen, 9005-79-2; glycosylated hemoglobin, 9062-63-9; insulin, 9004-10-8; nicotinamide, 11032-50-1, 98-92-0; streptozocin, 18883-66-4; urea, 57-13-6 References: Bailey, C.J., Day, C., Traditional treatment for diabetes (1989) Diabetes Care, 12, pp. 553-564; Bonner-Weir, S., Morphological evidence of pancreatic polarity of beta cells within islets of Langerhans (1988) Diabetes, 37, pp. 616-621; Donnini, D., Zambito, A.M., Perella, G., Ambesi, I.O., Curcio, F., Glucose may induce cell death through a free radical mediated mechanism (1996) Biochem Biophys Res Commun, 21, pp. 412-417; Ghosh, M.N., Toxicity studies (1984) Fundamentals of Experimental Pharmacology, pp. 153-158. , Calcutta, Scientific Book Agency, pp; Gingsberg, H.N., Lipoprotein metabolism and its relationship to atherosclerosis (1994) Med Clin North Am, 78, pp. 1-20; Grover, J.K., Vats, V., Rathi, S.S., Antihyperglycaemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism (2000) J Ethnopharmacol, 73, pp. 461-470; Grundy Jr, S.M., Ahrens, E.H., Davidnon, J., The interaction of cholesterol absorption and cholesterol synthesis in man (1969) J Lipid Res, 10, pp. 304-315; Harborne, J.B., Methods of extraction and isolation (1998) Phytochemical Methods, pp. 60-66. , London, Chapman & Hall, pp; Jouad, H., Lemhadri, A., Maghrani, M., Ali Zeggwah, N., Eddouks, M., Cholesterol lowering activity of the aqueous extract of Spergularia in normal and recent onset diabetic rats (2003) J Ethnopharmacol, 87, pp. 43-49; Kavalali, G., Tuncel, H., Goksel, S., Hatemi, H.H., Hypoglycemic activity of Urtica pilurifera in streptozotocindiabetic rats (2002) J Ethnopharmacol, 84, pp. 241-245; Khan, B.A., Abraham, A., Leelamma, S., Hypoglycemic action of Murraya koenigii (curry leaf), Brassica juncea (mustard): Mechanism of action (1995) Indian J Biochem Biophys, 32, pp. 106-108; Kokate, C.K., (1994) Preliminary Phytochemical Screening, Practical Pharmacognosy, pp. 107-113. , New Delhi, Vallabh Prakashan, pp; Krishnan Nambier, V.P., Jayanthi, A., Sabu, T.K., Rajendrakumar, K., Pharmacognostical studies on Jivanti (Holostemma Ada-Kodien Schult.) (1997) Aryavaidyan 11, 1, pp. 37-51; Lees, A.M., Mok, H.Y.L., Lees, R.S., McCluskey, M.A., Grundy, S.M., Plant sterol as cholesterol lowering agents: Clinical trials in patients with hypercholesterolemia and studies of sterol balance (1977) Atherosclerosis, 28, pp. 325-338; Lin, C.C., Crude drugs used for the treatment of diabetes mellitus in Taiwan (1992) Am J Chin Med, 20, pp. 269-279; Luc, G., Fruchart, J.C., Oxidation of lipoproteins and atherosclerosis (1991) Am J Clin Nutr, 53, pp. 2065-2095; Mitra, S.K., Gopumadhavan, S., Muralidhar, T.S., Anturlikar, S.D., Sujatha, M.B., Effect of D-400, a herbomineral preparation on lipid profile, glycated hemoglobin and glucose tolerance in STZ induced diabetes in rats (1995) Indian J Exp Biol, 33, pp. 798-800; Mohamed, A.K., Bierhaus, A., Schiekofer, S., Tritschler, H., Ziegler, H., Nawroth, P.P., The role of oxidative stress and NF (B) activation in late diabetic complications (1999) Biofactors, 10, pp. 175-179; Nicholas, V., The determination of glycogen in liver and muscle by the use of anthrone reagent (1956) Indian J Biol Chem, 220, p. 583; Nikkila, E.A., Kekki, M., Plasma transport kinetics in diabetes mellitus (1973) Metabolism, 22, pp. 1-5; Ozturk, Y., Altan, V.M., Yildizoglu, A., Effects of experimental diabetes and insulin on smooth muscle functions (1996) Pharmacol Rev, 48, pp. 69-112; Palmer, A.M., Thomas, C.R., Gopaul, N., Dhir, S., Anggard, E.E., Poston, L., Tribe, R.M., Dietary antioxidant supplementation reduces lipid peroxidation but impairs vascular function in small mescentric arteries of the streptozotocin diabetic rats (1998) Diabetologia, 41, pp. 148-152; Pellegrino, M., Broca, C., Gross, R., Roye, R.M., Manteghetti, M., Hillarie-Buys, D., Novelli, M., Ribes, G., Development of a new model of type 2 diabetes in adult rats administered with streptozotocin and nicotinamide (1998) Diabetes, 47, p. 224; Prasannan, K.G., Subrahmanyam, K., Effects of insulin on the glycogen synthesis in vivo the brain and liver of rats under different conditions (1965) Indian J Med Res, 53, p. 1003; Punitha, I.S.R., Rajendran, K., Shirwaikar, A.A., Shirwaikar, A., Alcoholic stem extract of Coscinium fenestratum: Regulates carbohydrate metabolism and improves antioxidant tatus in type 2 diabetic rats (2005) J Evidence Based Complementary Alternative Med, 2 (3), pp. 375-381; Ramiah, N., Nair, G.A., Prasad, N.B.R., Chemical components of Holostemma annulare K. Schum (1981) Planta Med, 2, pp. 76-78; Sachdewa, A., Khemani, L.D., Effect of Hibiscus rosa sinensis Linn. ethanol flower extract on blood glucose and lipid profile in STZ induced diabetes in rats (2003) J Ethnopharmacol, 89, pp. 61-66; Shirwaikar, A., Rajendran, K., Punitha, I.S.R., Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in STZ-Nicotinamide induced type 2 diabetic rats (2005) J Ethnopharmacol, 97, pp. 369-374; Swanston-Flat, S.K., Day, C., Bailey, C.J., Flatt, P.R., Traditional plant treatments for diabetes: Studies in normal and streptozotocin diabetic mice (1990) Diabetologia, 33, pp. 462-464; Turner, M.A., Screening of drugs with antidiabetic activity (1965) Screening Methods in Pharmacology, p. 26. , New York, Academic Press, p; Vats, V., Yadav, S.P., Grover, J.K., Effect of T. foenum graecum on glycogen content of tissues and the key enzymes of carbohydrate metabolism (2003) J Ethnopharmacol, 85, pp. 237-242; The Wealth of India (1950): Holostemma annulare. In: A Dictionary of Indian Raw Materials and Industrial Products. Delhi, India, CSIR, p. 111; Diabetes mellitus: Report of a WHO Study Group (1985) WHO Technical Report Series, 727, pp. 22-27. , World Health Organization , Geneva, WHO, pp",
year = "2007",
doi = "10.1080/13880200701388989",
language = "English",
volume = "45",
pages = "440--445",
journal = "Pharmaceutical Biology",
issn = "1388-0209",
publisher = "Informa Healthcare",
number = "6",
}
