TY - JOUR
T1 - Antidiabetic activity of alcohol root extract of Holostemma annulare in NIDDM rats
AU - Shirwaikar, A.
AU - Punitha, I.S.R.
AU - Upadhye, M.
AU - Dhiman, A.
N1 - Cited By :4
Export Date: 10 November 2017
CODEN: PHBIF
Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India; email: [email protected]
Chemicals/CAS: creatinine, 19230-81-0, 60-27-5; glucose, 50-99-7, 84778-64-3; glycogen, 9005-79-2; glycosylated hemoglobin, 9062-63-9; insulin, 9004-10-8; nicotinamide, 11032-50-1, 98-92-0; streptozocin, 18883-66-4; urea, 57-13-6
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In: A Dictionary of Indian Raw Materials and Industrial Products. Delhi, India, CSIR, p. 111; Diabetes mellitus: Report of a WHO Study Group (1985) WHO Technical Report Series, 727, pp. 22-27. , World Health Organization , Geneva, WHO, pp
PY - 2007
Y1 - 2007
N2 - The antidiabetic potential of the alcohol root extract of Holostemma annulare Schum. (Asclepiadaceae), a medicinal plant widely used in more than 34 Ayurvedic preparations, was evaluated in the streptozotocin-nicotinamide-induced type 2 diabetic model. Graded doses of the alcohol root extract were administered to normal and experimental diabetic rats for 15 days. A significant (p <0.05) reduction was observed in the fasting blood glucose levels of normal as well as diabetic rats. Serum insulin levels were stimulated in the diabetic animals treated with the extract. Body weight, serum lipid profiles, serum urea and creatinine levels were estimated in extract-treated normal and diabetic rats. In addition, glycosylated hemoglobin and liver glycogen levels assessed in the extract-treated diabetic rats were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the treatment of diabetes mellitus. © 2007 Informa Healthcare.
AB - The antidiabetic potential of the alcohol root extract of Holostemma annulare Schum. (Asclepiadaceae), a medicinal plant widely used in more than 34 Ayurvedic preparations, was evaluated in the streptozotocin-nicotinamide-induced type 2 diabetic model. Graded doses of the alcohol root extract were administered to normal and experimental diabetic rats for 15 days. A significant (p <0.05) reduction was observed in the fasting blood glucose levels of normal as well as diabetic rats. Serum insulin levels were stimulated in the diabetic animals treated with the extract. Body weight, serum lipid profiles, serum urea and creatinine levels were estimated in extract-treated normal and diabetic rats. In addition, glycosylated hemoglobin and liver glycogen levels assessed in the extract-treated diabetic rats were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the treatment of diabetes mellitus. © 2007 Informa Healthcare.
U2 - 10.1080/13880200701388989
DO - 10.1080/13880200701388989
M3 - Article
SN - 1388-0209
VL - 45
SP - 440
EP - 445
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
IS - 6
ER -
SDG 3 Good Health and Well-being