TY - JOUR
T1 - Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats
AU - Shirwaikar, A.
AU - Rajendran, K.
AU - Punitha, I.S.R.
N1 - Cited By :97
Export Date: 10 November 2017
CODEN: JOETD
Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal Coll. of Pharmaceutical Sci., Manipal 576 104, India; email: annieshirwaikar@yahoo.com
Chemicals/CAS: glycosylated hemoglobin, 9062-63-9; nicotinamide, 11032-50-1, 98-92-0; streptozocin, 18883-66-4
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Ethanol flower extract on blood glucose and lipid profile in STZ induced diabetes in rats (2003) Journal of Ethnopharmacology, 89, pp. 61-66; Sharma, S.R., Dwivedi, S.K., Swarup, D., Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia sylvestre seeds in rats (1997) Journal of Ethnopharmacology, 58, pp. 39-44; Singh, G.B., Singh, S., Bani, S., Malhotra, S., Hypotensive action of a Coscinium fenestratum stem extract (1990) Journal of Ethnopharmacology, 38, pp. 151-155; Suresh Kumar, J.S., Menon, V.P., Effect of diabetes on levels of lipid peroxides and glycolipids in rat brain (1993) Metabolism, 42, pp. 1435-1439; Swanston-Flat, S.K., Day, C., Bailey, C.J., Flatt, P.R., Traditional plant treatments for diabetes: Studies in normal and streptozotocin diabetic mice (1990) Diabetologia, 33, pp. 462-464; Wealth Of India, T., Coscinium fenestratum (1950) A Dictionary of Indian Raw Materials and Industrial Products, , CSIR Delhi, India; Turner, M.A., (1965) Screening Methods in Pharmacology, , Academic Press New York; Varier, P.S., (1994) Indian Medicinal Plants Compendium of 500 Species, 2. , Orient Longmann Ltd. Hyderabad; Venkateswaran, S., Pari, L., Effect of Coccinia indica leaves on antioxidant status in streptozotocin induced diabetic rats (2003) Journal of Ethnopharmacology, 84, pp. 163-168; Yin, J., Hu, R., Chen, M., Tang, J., Li, F., Yang, Y., Cheng, J., Effects of berberine on glucose metabolism in vitro (2002) Metabolism, 51, pp. 1439-1443
PY - 2005
Y1 - 2005
N2 - The antidiabetic potential of the alcoholic stem extract of Coscinium fenestratum Colebr. (Menispermaceae), a medicinal plant widely used in the traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus was evaluated in the STZ-nicotinamide induced type 2 diabetic model. Graded doses of the alcoholic stem extract were administered to normal and experimental diabetic rats for 12 days. Significant (p <0.05) reduction in fasting blood glucose levels were observed in the normal as well as in the treated diabetic animals. Serum insulin levels were not stimulated in the animals treated with the extract. In addition, changes in body weight, serum lipid profiles, thiobarbituric acid reactive substance levels, glycosylated hemoglobin and liver glycogen levels assessed in the extract treated diabetic rats were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the indigenous system of medicine. © 2004 Elsevier Ireland Ltd. All rights reserved.
AB - The antidiabetic potential of the alcoholic stem extract of Coscinium fenestratum Colebr. (Menispermaceae), a medicinal plant widely used in the traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus was evaluated in the STZ-nicotinamide induced type 2 diabetic model. Graded doses of the alcoholic stem extract were administered to normal and experimental diabetic rats for 12 days. Significant (p <0.05) reduction in fasting blood glucose levels were observed in the normal as well as in the treated diabetic animals. Serum insulin levels were not stimulated in the animals treated with the extract. In addition, changes in body weight, serum lipid profiles, thiobarbituric acid reactive substance levels, glycosylated hemoglobin and liver glycogen levels assessed in the extract treated diabetic rats were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the indigenous system of medicine. © 2004 Elsevier Ireland Ltd. All rights reserved.
U2 - 10.1016/j.jep.2004.11.034
DO - 10.1016/j.jep.2004.11.034
M3 - Article
SN - 0378-8741
VL - 97
SP - 369
EP - 374
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 2
ER -
