Antidiabetic, hypolipidaemic and antioxidant activity of Dodonaea viscosa aerial parts in streptozotocin-induced diabetic rats

V.P. Veerapur, K.R. Prabhakar, V.K. Parihar, P. Bansal, K.K. Srinivasan, K.I. Priyadarsini, M.K. Unnikrishnan

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We evaluated the antidiabetic and antioxidant activity of Dodonaea viscosa in streptozotocin-induced diabetic rats. The water extract (DVW) and polar fraction of ethanol extract (DVE-4) in a single-dose one-day study showed dose-dependent reduction in glucose levels with maximum effect of 42.16% and 72.9% respectively at 6 h post drug treatment (p<0.001). DVE-4 was more active than DVW and glibenclamide. In a multi-dose fifteen-day study, lower doses of DVW (400 mg/kg) and DVE-4 (200 mg/kg) exhibited higher percentage reduction in glucose levels compared to glibenclamide treated group. Altered levels of lipids, TBARS, non-enzymatic and enzymatic antioxidants were restored by DVW (400 mg/kg) and DVE-4 (200 mg/kg) in diabetic rats. In vitro steady state and time resolved studies reveled that DVW and DVE-4 showed comparable antioxidant ability in steady state and kinetic studies suggesting its possible role in observed antidiabetic and hypolipidaemic activities.
Original languageUndefined/Unknown
Pages (from-to)59-70
Number of pages12
JournalInternational Journal of Phytomedicine
Issue number1
Publication statusPublished - 2010

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