Abstract
Original language | English |
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Pages (from-to) | 909-916 |
Number of pages | 8 |
Journal | Journal of Pharmacy and Pharmacology |
Volume | 60 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2008 |
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In: Journal of Pharmacy and Pharmacology, Vol. 60, No. 7, 2008, p. 909-916.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Antidiabetic properties of the alcoholic extract of Sphaeranthus indicus in streptozotocin-nicotinamide diabetic rats
AU - Prabhu, K.S.
AU - Lobo, R.
AU - Shirwaikar, A.
N1 - Cited By :25 Export Date: 10 November 2017 CODEN: JPPMA Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Science, Manipal-576104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: alcohol, 64-17-5; glibenclamide, 10238-21-8; glucose, 50-99-7, 84778-64-3; glycogen, 9005-79-2; glycosylated hemoglobin, 9062-63-9; insulin, 9004-10-8; lipid, 66455-18-3; magnesium, 7439-95-4; nicotinamide, 11032-50-1, 98-92-0; streptozocin, 18883-66-4; Blood Glucose; Hemoglobin A, Glycosylated; Hypoglycemic Agents; Insulin, 11061-68-0; Lipids; Liver Glycogen; Magnesium, 7439-95-4; Niacinamide, 98-92-0; Plant Extracts; Streptozocin, 18883-66-4 References: Ambavade, S.D., Mhetre, N.A., Tate, V.D., Bodhankar, S.L., Pharmacological evaluation of the extracts of Sphaearanthus indicus flowers on anxiolytic activity in mice (2006) Indian J. 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Med, 295, pp. 417-420; Lopez-Ridaura, R., Willett, W.C., Rimm, E.B., Liu, S., Stampfer, M.J., Manson, J.E., Hu, F.B., Magnesium intake and risk of type 2 diabetes in men and women (2004) Diabetes Care, 27, pp. 134-140; Masiello, P., Broca, C., Gross, R., Roye, M., Manteghetti, M., Hillaire-Buys, D., Novelli, M., Ribes, G., Development of a new model of type 2 diabetes in adult rats administered with streptozotocin and nicotinamide (1998) Diabetes, 47, pp. 224-230; Nicholas, V., Robert, W.L., Roe, J.H., The determination of glycogen in liver and muscle by use of anthrone reagent (1956) J. Biol. Chem, 220, pp. 583-593; Nikkila, E.A., Kekki, M., Plasma transport kinetics in diabetes mellitus (1973) Metabolism, 22, p. 1; Paranjape P. (2001) Indian medicinal plants. In: Paranjape, P. (ed) Forgotten healer a guide to Ayurvedic herbal medicine. 1st edn, Chaukhamba Sanskrit Pratisthan, Delhi, India, pp 148-149; Rahman, A.U., Zaman, K., Medicinal plants with hypoglycaemic activity (1989) J. Ethnopharmacol, 26, pp. 1-55; Rajkumar, L., Srinivasan, N., Balasubramanian, K., Govindarajulu, P., Increased degradation of dermal collagen in diabetic rats (1991) Indian J. Exp. Biol, 29, pp. 1081-1083; Sadaf, F., Saleem, R., Ahmed, M., Ahmad, S., Navaid-ul-Zafar, I., Healing potential of cream containing extract of Sphaeranthus indicus on dermal wounds in Guinea pigs (2006) J. Ethnopharmacol, 107, pp. 161-163; Sasaki, T., Matsy, S., Sonae, A., Effect of acetic acid concentration on the colour reaction in the o-toluidine boric acid method for blood glucose estimation (1972) Rinsho. Kagaku, 1, pp. 346-353; Setter, M.S., White, J.R., Campbell, R.K., Diabetes mellitus (2000) Herfindals Textbook of therapeutic drug and disease management, pp. 377-405. , 6th edn. Philadelphia, Lippincott William & Willkins. pp; Sheikh, D., Naqvi, B.S., Shaikh, R., The antibacterial principles of Sphaeranthus indicus isolation, purification and antimicrobial action (1986) Pak. J. Sci. Ind. Res, 25, pp. 366-371; Shekhani, M.S., Shah, P.M., Yasmin, A., Siddiqui, R., Perveen, S., Khan, K.M., ur-Rehman, A., An immunostimulant sesquiterpene glycoside from Sphaeranthus indicus (1990) Phytochemistry, 29, pp. 2573-2576; Shirwaikar, A., Rajendran, K., Kumar, C.D., Oral antidiabetic activity of Annona squamosa leaf alcohol extract in NIDDM rats (2004) Pharm. Biol, 42, pp. 30-35; Shirwaikar, A., Rajendran, K., Punitha, I.S.R., Antihyperglycemic activity of the aqueous stem extract of Coscinium fenestratum in non-insulin dependent diabetic rats (2005) Pharmacol. Biol, 43, pp. 707-712; Shirwaikar, A., Prabhu, K., Kumar, C.D., Rajendran, K., Lobo, R., Pharmacognostical evaluation of Sphaeranthus indicus (Linn) (2006) Nat Prod. Sci, 12, pp. 85-88; Singh, S.N., Vats, P., Suri, S., Shyam, R., Kumria, M.M., Ranganathan, S., Sridharan, K., Effect of an antidiabetic extract of Cathanranthus roseus on enzymatic activities in streptozotocin induced diabetic rats (2001) J. Ethnopharmacol, 76, pp. 269-277; Srivastawa, S.C., Khan, M.S., Vohra, S.B., Pharmacological and haemostatic investigations on Sphaeranthus indicus Linn (1971) Indian J. Physiol. Pharmacol, 15, pp. 27-33; Subash Babu, P., Prince, S.M., Antihyperglycaemic and antioxidant effect of hyponidd, an ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats (2004) J. Pharm. Pharmacol, 56, pp. 1435-1442; Tietz, N. W., Wu, A. H. B.(1995) In: Tietz, N. W., Wu, A. H. B.(eds) Tietz clinical guide to laboratory tests. 3rd edn, WB Saunders, Philadelphia, pp 130-131, 610-611, 824-843; Vertommen, J., Van den Enden, M., Simoens, L., De Leeuw, I., Flavonoid treatment reduces glycation and lipid peroxidation in experimental diabetic rats (1994) Phytother. Res, 8, pp. 430-432; Whitton, P.D., Hems, D.A., Glycogen synthesis in perfused liver of streptozotocin diabetic rats (1975) Biochem. 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PY - 2008
Y1 - 2008
N2 - We have investigated the possible antihyperglycaemic effects of Sphaeranthus indicus extract in rats rendered diabetic by nicotinamide (120 mg kg-1 i.p.) and streptozotocin (STZ) (60 mg kg-1 i.p). Fasting plasma glucose levels, serum insulin levels, serum lipid profiles, magnesium levels, glycosylated haemoglobin, changes in body weight and liver glycogen levels were evaluated in normal and diabetic rats. Oral administration of S. indicus for 15 days resulted in significant decrease in blood glucose levels and increases in hepatic glycogen and plasma insulin levels. Fasting normal rats treated with the alcoholic extract of S. indicus showed significant improvement in oral glucose tolerance test. Glibenclamide was used as a reference standard. The findings demonstrate that the alcoholic S. indicus extract may be useful in the treatment of diabetes.
AB - We have investigated the possible antihyperglycaemic effects of Sphaeranthus indicus extract in rats rendered diabetic by nicotinamide (120 mg kg-1 i.p.) and streptozotocin (STZ) (60 mg kg-1 i.p). Fasting plasma glucose levels, serum insulin levels, serum lipid profiles, magnesium levels, glycosylated haemoglobin, changes in body weight and liver glycogen levels were evaluated in normal and diabetic rats. Oral administration of S. indicus for 15 days resulted in significant decrease in blood glucose levels and increases in hepatic glycogen and plasma insulin levels. Fasting normal rats treated with the alcoholic extract of S. indicus showed significant improvement in oral glucose tolerance test. Glibenclamide was used as a reference standard. The findings demonstrate that the alcoholic S. indicus extract may be useful in the treatment of diabetes.
U2 - 10.1211/jpp.60.7.0013
DO - 10.1211/jpp.60.7.0013
M3 - Article
SN - 0022-3573
VL - 60
SP - 909
EP - 916
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 7
ER -