@article{de6bcb32120d4daf8fd9c5d358b031ed,
title = "Antidiabetic properties of the alcoholic extract of Sphaeranthus indicus in streptozotocin-nicotinamide diabetic rats",
abstract = "We have investigated the possible antihyperglycaemic effects of Sphaeranthus indicus extract in rats rendered diabetic by nicotinamide (120 mg kg-1 i.p.) and streptozotocin (STZ) (60 mg kg-1 i.p). Fasting plasma glucose levels, serum insulin levels, serum lipid profiles, magnesium levels, glycosylated haemoglobin, changes in body weight and liver glycogen levels were evaluated in normal and diabetic rats. Oral administration of S. indicus for 15 days resulted in significant decrease in blood glucose levels and increases in hepatic glycogen and plasma insulin levels. Fasting normal rats treated with the alcoholic extract of S. indicus showed significant improvement in oral glucose tolerance test. Glibenclamide was used as a reference standard. The findings demonstrate that the alcoholic S. indicus extract may be useful in the treatment of diabetes.",
author = "K.S. Prabhu and R. Lobo and A. Shirwaikar",
note = "Cited By :25 Export Date: 10 November 2017 CODEN: JPPMA Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Science, Manipal-576104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: alcohol, 64-17-5; glibenclamide, 10238-21-8; glucose, 50-99-7, 84778-64-3; glycogen, 9005-79-2; glycosylated hemoglobin, 9062-63-9; insulin, 9004-10-8; lipid, 66455-18-3; magnesium, 7439-95-4; nicotinamide, 11032-50-1, 98-92-0; streptozocin, 18883-66-4; Blood Glucose; Hemoglobin A, Glycosylated; Hypoglycemic Agents; Insulin, 11061-68-0; Lipids; Liver Glycogen; Magnesium, 7439-95-4; Niacinamide, 98-92-0; Plant Extracts; Streptozocin, 18883-66-4 References: Ambavade, S.D., Mhetre, N.A., Tate, V.D., Bodhankar, S.L., Pharmacological evaluation of the extracts of Sphaearanthus indicus flowers on anxiolytic activity in mice (2006) Indian J. 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year = "2008",
doi = "10.1211/jpp.60.7.0013",
language = "English",
volume = "60",
pages = "909--916",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
publisher = "Pharmaceutical Press",
number = "7",
}
