Antifungal susceptibility and phenotypic virulence markers of Candida species isolated from Nepal

Supram Hosuru Subramanya, Bharat Prasad Baral, Nawal Kishor Sharan, Niranjan Nayak, Yang Metok, Brijesh Sathian, Indira Bairy, Shishir Gokhale

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Objective: Candida species are part of the commensal microflora in many anatomical sites of the human body; however, breach in the integrity of the body part and impaired immunity of the host can lead to invasive candidiasis. A number of virulence determinants could contribute towards its pathogenicity. Thus we attempted to evaluate the in vitro expression of different virulence factors among clinical isolates of Candida species and assayed their susceptibility patterns against a range of antifungal agents. Result: Of the total of 71 isolates we obtained, 48 (67.6%) were Candida albicans, 11 (15.49%) Candida tropicalis, 09 (12.67%) Candida glabrata and 03 (4.22%) were Candida krusei. Proteinase, phospholipase and esterase production could be revealed amongst 43 (60.56%), 44 (61.97%) and 49 (69.01%) isolates respectively. None of the isolates showed DNAase activity. Fifty-five (77.39%) isolates were biofilm producers, and 53 (74.6%) exhibited high cell surface hydrophobicity.

Original languageEnglish
Article number543
JournalBMC Research Notes
Issue number1
Publication statusPublished - 02-11-2017

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology


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