TY - JOUR
T1 - Antiinflammatory and antiulcer activities of phytic acid in rats
AU - Sudheer Kumar, M.
AU - Sridhar Reddy, B.
AU - Kiran Babu, S.
AU - Bhilegaonkar, P.M.
AU - Shirwaikar, A.
AU - Unnikrishnan, M.K.
N1 - Cited By :18
Export Date: 10 November 2017
CODEN: IJEBA
Correspondence Address: Unnikrishnan, M.K.; Department of Pharmacology, College of Pharmaceutical Sciences, Manipal 576 119, India; email: cheruvaloor@yahoo.com
Chemicals/CAS: alcohol, 64-17-5; famotidine, 76824-35-6; ibuprofen, 15687-27-1; malonaldehyde, 542-78-9; phytic acid, 83-86-3; thiol derivative, 13940-21-1; Anti-Inflammatory Agents; Anti-Ulcer Agents; Ethanol, 64-17-5; Famotidine, 76824-35-6; Ibuprofen, 15687-27-1; Malondialdehyde, 542-78-9; Phytic Acid, 83-86-3; Plant Extracts; Sulfhydryl Compounds
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Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury (1979) Gastroenterology, 77, p. 433; Naito, Y., Yoshikawa, T., Matsuyama, K., Yagi, N., Aral, M., Nakamura, S., Yoshida, N., Konda, M., Effect of oxygen radical scavengers on the quality of gastric ulcer healing in rats (1995) J Clin Gastroenterol, 21, pp. S82; Desai, J.K., Goyal, R.K., Parmar, N.S., Pathogenesis of peptic ulcer disease and current trends in therapy (1997) Indian J Physio Pharmacol, 41, p. 3; Szelenyi, I., Brune, K., Possible role of free radicals in ethanol-induced gastric mucosal damage in rats (1988) Dig Dis Sci, 33, p. 865; Szabo, S., Trier, J.S., Frankel, P.W., Sulfhydryl compounds may mediate gastric cytoprotection (1981) Science, 214, p. 200; Hua, X.Y., Dahlen, S.E., Lundberg, J.M., Hammerstrom, S., Hedqvist, P., Leckotrienes C4, D4, E4 cause wide spread and extensive plasma extravasation in the guineapig (1985) Naunyn-Schmiedeberg's Arch Pharmacol, 330, p. 136; Bandyopadhyay, U., Das, D., Bandyopadhyay, D., Bhattacharjee, M., Banerjee, R.K., Role of reactive oxygen species in mercaptomethylimidazole-induced gastric acid secretion and stress-induced gastric ulceration (1999) Curr Sci, 76, p. 55; Holley, A.E., Cheeseman, K.H., Measuring free radical reaction in vivo (1993) Br Med Bull, 49, p. 407; Al-Harabi, M.M., Qureshi, S., Raza, M., Ahmed, M.M., Afzal, M., Shah, A.H., Evaluation of caralluma tuberculata pretreatment for the protection of rat gastric mucosa against toxic damage (1994) Toxicol Applied Pharmacol, 128, p. 1; Al-Bekairi, A.M., Qureshi, S., Ahmed, M.M., Afzal, M., Shah, A.H., A study of uric acid pretreatment for the protection of gastric mucosa against toxic damage (1992) Food Chem Toxicol, 30, p. 525; Phillipy, B.Q., Graf, E., Antioxidant functions of inositol 1,2,3-triphosphate and inositol 1,2,3,6-tetrakisphosphate (1997) Free Radical Biol Med, 22, p. 939; Albin, J., Shalev, O., Karmeli, F., Rachmilewitz, D., Deferiprone, an oral iron chelator, ameliorates experimental colitis and gastric ulceration in rats (1999) Inflamm Bowel Dis, 5, p. 253; Singh, A., Singh, S.P., Bamezai, R., Modulatory influence of arecoline on phytic acid altered hepatic biotransformation system enzymes, sulfhydryl content and lipid peroxidation in a murine system (1997) Cancer Lett, 117, p. 1
PY - 2004
Y1 - 2004
N2 - Maximum antiinflammatory activity of phytic acid (PA) was seen at an oral dose of 150 mg/kg in the carrageenan induced rat paw edema model. Although PA showed ability to prevent denaturation of proteins, it showed less antiinflammatory activity than ibuprofen. Ability of PA to bring down thermal denaturation of proteins might be a contributing factor in the mechanism of action against inflammation. PA, at all the doses tested, showed significant protection from ulcers induced by ibuprofen, ethanol and cold stress, with a maximum activity at 150 mg/kg. There was a significant increase in gastric tissue malondialdehyde levels in ethanol treated rats but these levels decreased following PA pretreatment, Moreover, pretreatment with PA significantly inhibited various effects of ethanol on gastric mucosa, such as, reduction in the concentration of nonprotein sulfhydryl groups, necrosis, erosions, congestion and hemorrhage. These results suggested that gastro-protective effect of PA could be mediated by its antioxidant activity and cytoprotection of gastric mucosa.
AB - Maximum antiinflammatory activity of phytic acid (PA) was seen at an oral dose of 150 mg/kg in the carrageenan induced rat paw edema model. Although PA showed ability to prevent denaturation of proteins, it showed less antiinflammatory activity than ibuprofen. Ability of PA to bring down thermal denaturation of proteins might be a contributing factor in the mechanism of action against inflammation. PA, at all the doses tested, showed significant protection from ulcers induced by ibuprofen, ethanol and cold stress, with a maximum activity at 150 mg/kg. There was a significant increase in gastric tissue malondialdehyde levels in ethanol treated rats but these levels decreased following PA pretreatment, Moreover, pretreatment with PA significantly inhibited various effects of ethanol on gastric mucosa, such as, reduction in the concentration of nonprotein sulfhydryl groups, necrosis, erosions, congestion and hemorrhage. These results suggested that gastro-protective effect of PA could be mediated by its antioxidant activity and cytoprotection of gastric mucosa.
M3 - Article
SN - 0019-5189
VL - 42
SP - 179
EP - 185
JO - Indian Journal of Experimental Biology
JF - Indian Journal of Experimental Biology
IS - 2
ER -