TY - JOUR
T1 - Antimicrobial peptide polymers
T2 - no escape to ESKAPE pathogens—a review
AU - Mukhopadhyay, Songhita
AU - Bharath Prasad, A. S.
AU - Mehta, Chetan H.
AU - Nayak, Usha Y.
N1 - Funding Information:
Open access funding provided by Manipal Academy of Higher Education, Manipal. The authors would like to express their sincere gratitude to Manipal Academy of Higher Education, Manipal, for providing facilities for the literature search and facilities to work in this area. Authors are also thankful to the Indian Council of Medical Research (ICMR), New Delhi, Ref. No 2020–4549 for the fund support.
Funding Information:
Open access funding provided by Manipal Academy of Higher Education, Manipal. The authors would like to express their sincere gratitude to Manipal Academy of Higher Education, Manipal, for providing facilities for the literature search and facilities to work in this area. Authors are also thankful to the Indian Council of Medical Research (ICMR), New Delhi, Ref. No 2020?4549 for the fund support.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Abstract: Antimicrobial resistance (AMR) is one of the significant clinical challenges and also an emerging area of concern arising from nosocomial infections of ESKAPE pathogens, which has been on the rise in both the developed and developing countries alike. These pathogens/superbugs can undergo rapid mutagenesis, which helps them to generate resistance against antimicrobials in addition to the patient’s non-adherence to the antibiotic regimen. Sticking to the idea of a ‘one-size-fits-all’ approach has led to the inappropriate administration of antibiotics resulting in augmentation of antimicrobial resistance. Antimicrobial peptides (AMPs) are the natural host defense peptides that have gained attention in the field of AMR, and recently, synthetic AMPs are well studied to overcome the drawbacks of natural counterparts. This review deals with the novel techniques utilizing the bacteriolytic activity of natural AMPs. The effective localization of these peptides onto the negatively charged bacterial surface by using nanocarriers and structurally nanoengineered antimicrobial peptide polymers (SNAPPs) owing to its smaller size and better antimicrobial activity is also described here. Graphic abstract: [Figure not available: see fulltext.]
AB - Abstract: Antimicrobial resistance (AMR) is one of the significant clinical challenges and also an emerging area of concern arising from nosocomial infections of ESKAPE pathogens, which has been on the rise in both the developed and developing countries alike. These pathogens/superbugs can undergo rapid mutagenesis, which helps them to generate resistance against antimicrobials in addition to the patient’s non-adherence to the antibiotic regimen. Sticking to the idea of a ‘one-size-fits-all’ approach has led to the inappropriate administration of antibiotics resulting in augmentation of antimicrobial resistance. Antimicrobial peptides (AMPs) are the natural host defense peptides that have gained attention in the field of AMR, and recently, synthetic AMPs are well studied to overcome the drawbacks of natural counterparts. This review deals with the novel techniques utilizing the bacteriolytic activity of natural AMPs. The effective localization of these peptides onto the negatively charged bacterial surface by using nanocarriers and structurally nanoengineered antimicrobial peptide polymers (SNAPPs) owing to its smaller size and better antimicrobial activity is also described here. Graphic abstract: [Figure not available: see fulltext.]
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U2 - 10.1007/s11274-020-02907-1
DO - 10.1007/s11274-020-02907-1
M3 - Review article
AN - SCOPUS:85088904575
SN - 0265-0762
VL - 36
JO - Mircen Journal of Applied Microbiology and Biotechnology
JF - Mircen Journal of Applied Microbiology and Biotechnology
IS - 9
M1 - 131
ER -