TY - JOUR
T1 - Antinuclear antibodies in suspected Systemic lupus erythematosus (SLE) patients of a tertiary care hospital-a retrospective study
AU - Patil, Asha
AU - Chaitra, null
AU - Kamath, Deepa
AU - Bairy, Indira
AU - Nayak, Kusumakshi
N1 - Funding Information:
Staff of Department of Microbiology, KMC, Manipal for their support in data collection.
Publisher Copyright:
© 2022, Ibn Sina Trust. All rights reserved.
PY - 2022/2/25
Y1 - 2022/2/25
N2 - Background: In a systemic autoimmune disorder, non-organ-specific autoantibodies binding to the antigens are expressed within the human cells. The presence of antinuclear antibody (ANA) in the blood indicate an autoimmune disease. Objective: The study aims to estimate the frequency and prevalence of ANA in suspected autoimmune disorders in a tertiary care hospital. Materials and methods: A retrospective study and the ANA test results data obtained from the Laboratory Information System and laboratory records. Result: The frequency of the ANA test in six months was 5879; among them, 1638 (27.8 %) had ANA positive test either global or profile with female predominance (2:1). ANA positive test selected for further analysis was 401, in which 154(38%) were from the age group of 20 to 40 years. Conclusion: The estimated prevalence of ANA positive tests was 27.8%, which differed in different sex and age groups. In autoimmune conditions, estimating the prevalence of ANAs influences the trends of antinuclear antibodies. The test frequency and its interpretation assist in patient diagnosis and management, along with specific diagnostic tests.
AB - Background: In a systemic autoimmune disorder, non-organ-specific autoantibodies binding to the antigens are expressed within the human cells. The presence of antinuclear antibody (ANA) in the blood indicate an autoimmune disease. Objective: The study aims to estimate the frequency and prevalence of ANA in suspected autoimmune disorders in a tertiary care hospital. Materials and methods: A retrospective study and the ANA test results data obtained from the Laboratory Information System and laboratory records. Result: The frequency of the ANA test in six months was 5879; among them, 1638 (27.8 %) had ANA positive test either global or profile with female predominance (2:1). ANA positive test selected for further analysis was 401, in which 154(38%) were from the age group of 20 to 40 years. Conclusion: The estimated prevalence of ANA positive tests was 27.8%, which differed in different sex and age groups. In autoimmune conditions, estimating the prevalence of ANAs influences the trends of antinuclear antibodies. The test frequency and its interpretation assist in patient diagnosis and management, along with specific diagnostic tests.
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U2 - 10.3329/bjms.v21i2.58059
DO - 10.3329/bjms.v21i2.58059
M3 - Article
AN - SCOPUS:85125615515
SN - 2223-4721
VL - 21
SP - 279
EP - 283
JO - Bangladesh Journal of Medical Science
JF - Bangladesh Journal of Medical Science
IS - 2
ER -
