TY - JOUR
T1 - Antioxidant activity of aqueous extract of Coscinium fenestratum in STZ-nicotinamide induced diabetic rats
AU - Punitha, I.S.R.
AU - Bhat, N.
AU - Rajendran, K.
AU - Shirwaikar, A.
N1 - Export Date: 10 November 2017
CODEN: NPSCF
Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India; email: [email protected]
Chemicals/CAS: ascorbic acid, 134-03-2, 15421-15-5, 50-81-7; catalase, 9001-05-2; ceruloplasmin, 9031-37-2; glutathione peroxidase, 9013-66-5; glutathione synthase, 9023-62-5; nicotinamide, 11032-50-1, 98-92-0; peroxidase, 9003-99-0; streptozocin, 18883-66-4; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; tocopherol, 1406-66-2
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Siddha, 18, pp. 89-91; Masiello, P., Broca, C., Gross, R., Roye, M., Manteghetti, M., Hillaire-Buys, D., Novelli, M., Ribes, G., Development of a new model of type 2 diabetes in adult rats administered with Streptozotocin and nicotinamide (1998) Diabetes., 47, pp. 224-228; Omaye, S.T., Turnball, J.D., Sauberlich, H.E., Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids (1979) Methods in Enzymology, 62, pp. 1-11. , McCormick DB, Wright CD (Eds.), Academic press, New York; Ravin, H.A., An improved colorimetric assay of ceruloplasmin (1961) J. Labor. Clin. Med., 589, pp. 161-168; Rotruck, J.T., Pope, A.L., Ganther, H.E., Selenium biochemical role as a component of glutathione peroxide purification and assay (1973) Science, 179, pp. 588-590; Saxena, A.K., Srivastava, P., Kale, R.K., Impaired antioxidant status in diabetic rat liver: Effect of vandale (1993) Biochem. 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PY - 2005
Y1 - 2005
N2 - The aqueous extract of Coscinium fenestratum was studied for its antioxidant status in STZ-nicotinamide induced type 2 diabetic rats at two dose levels of 250 mg/kg and 500 mg/kg. At the end of the experimental period, diabetic rats treated with aqueous extract at both dose levels showed a significant increase in the levels of enzymatic antioxidants such as glutathione peroxidase, glutathione synthetase, peroxidase, superoxide dismutase and catalase as compared to the untreated control. Similarly, a significant increase was also observed in the levels of the non enzymatic antioxidants ceruloplasmin, ascorbic acid and tocopherol. The results suggest that the aqueous stem extract of C. fenestratum prevents type 2 diabetes mellitus induced oxidative stress.
AB - The aqueous extract of Coscinium fenestratum was studied for its antioxidant status in STZ-nicotinamide induced type 2 diabetic rats at two dose levels of 250 mg/kg and 500 mg/kg. At the end of the experimental period, diabetic rats treated with aqueous extract at both dose levels showed a significant increase in the levels of enzymatic antioxidants such as glutathione peroxidase, glutathione synthetase, peroxidase, superoxide dismutase and catalase as compared to the untreated control. Similarly, a significant increase was also observed in the levels of the non enzymatic antioxidants ceruloplasmin, ascorbic acid and tocopherol. The results suggest that the aqueous stem extract of C. fenestratum prevents type 2 diabetes mellitus induced oxidative stress.
M3 - Article
SN - 1226-3907
VL - 11
SP - 155
EP - 159
JO - Natural Product Sciences
JF - Natural Product Sciences
IS - 3
ER -
SDG 3 Good Health and Well-being