TY - JOUR
T1 - Antioxidant activity of Hypericum hookerianum Wight and Arn.
AU - Raghu Chandrashekhar, H.
AU - Venkatesh, P.
AU - Ponnusankar, S.
AU - Vijayan, P.
N1 - Cited By :6
Export Date: 10 November 2017
Correspondence Address: Raghu Chandrashekhar, H.email: [email protected]
Chemicals/CAS: catalase, 9001-05-2; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; Antioxidants; Catalase, 1.11.1.6; Plant Extracts; Superoxide Dismutase, 1.15.1.1
PY - 2009
Y1 - 2009
N2 - Methanolic extracts of leaf, root, flower and aerial parts of Hypericum hookerianum were assessed for in vitro antioxidant activity using eight different models. Total antioxidant capacity, phenol and flavanol content of the extracts were determined to correlate between their antioxidant activity and constituents present therein. Results of in vitro antioxidant study suggest that extracts from leaf and flower have strong antioxidant potential. Leaf extract (100 & 200 mg kg(-1) b.w. p.o.) that showed maximum activity was selected for in vivo antioxidant studies using a CCl(4)-intoxicated rat model. The effects of extracts on lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase (CAT) in serum and liver homogenate were analysed. CCl(4) treatment caused a significant increase in the level of CAT and SOD and a significant decrease in the level of LPO in a dose-dependent manner when compared to CCl(4) treated control. The results indicate the strong antioxidant nature of H. hookerianum leaf extract.
AB - Methanolic extracts of leaf, root, flower and aerial parts of Hypericum hookerianum were assessed for in vitro antioxidant activity using eight different models. Total antioxidant capacity, phenol and flavanol content of the extracts were determined to correlate between their antioxidant activity and constituents present therein. Results of in vitro antioxidant study suggest that extracts from leaf and flower have strong antioxidant potential. Leaf extract (100 & 200 mg kg(-1) b.w. p.o.) that showed maximum activity was selected for in vivo antioxidant studies using a CCl(4)-intoxicated rat model. The effects of extracts on lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase (CAT) in serum and liver homogenate were analysed. CCl(4) treatment caused a significant increase in the level of CAT and SOD and a significant decrease in the level of LPO in a dose-dependent manner when compared to CCl(4) treated control. The results indicate the strong antioxidant nature of H. hookerianum leaf extract.
M3 - Article
SN - 1478-6427
VL - 23
SP - 1240
EP - 1251
JO - Natural Product Research
JF - Natural Product Research
IS - 13
ER -