@article{c1ff61bdf35146149c73e8c7bf110cf1,
title = "Antioxidant for neurological diseases and neurotrauma and bioengineering approaches",
abstract = "Antioxidants are a class of molecules with an innate affinity to neutralize reactive oxygen species (ROS), which are known to cause oxidative stress. Oxidative stress has been associated with a wide range of diseases mediated by physiological damage to the cells. ROS play both beneficial and detrimental roles in human physiology depending on their overall concentration. ROS are an inevitable byproduct of the normal functioning of cells, which are produced as a result of the mitochondrial respiration process. Since the establishment of the detrimental effect of oxidative stress in neurological disorders and neurotrauma, there has been growing interest in exploring antioxidants to rescue remaining or surviving cells and reverse the neurological damage. In this review, we present the survey of different antioxidants studied in neurological applications including neurotrauma. We also delve into bioengineering approaches developed to deliver antioxidants to improve their cellular uptake in neurological applications.",
author = "Nasera Rizwana and Vipul Agarwal and Manasa Nune",
note = "Funding Information: Funding: This research was funded by Manipal Academy of Higher Education-University of New South Wales Collaborative Research Seed Funding, Department of Science & Technology Start-Up Research Grant, India, Grant Number SRG/2019/002130 and National Health & Medical Research Council, Australia, Early Career Fellowship, grant number GNT1139060 and The APC was funded by Manipal Academy of Higher Education. Funding Information: Acknowledgments: M.N. acknowledges the Manipal Academy of Higher Education, University of New South Wales Collaborative Research Seed Funding and the Department of Science & Technology, India for the SERB start-up research grant (SRG/2019/002130) for financial support. V.A. acknowledges the National Health and Medical Research Council (NHMRC), Australia for an Early Career Fellowship (GNT1139060). N.R. acknowledges T.M.A. Pai Ph.D. Scholarship from the Ma-nipal Academy of Higher Education. The authors also thank the Manipal Institute of Regenerative Medicine, MAHE for the infrastructural support. Funding Information: This research was funded by Manipal Academy of Higher Education-University of New South Wales Collaborative Research Seed Funding, Department of Science & Technology Start-Up Research Grant, India, Grant Number SRG/2019/002130 and National Health & Medical Research Council, Australia, Early Career Fellowship, grant number GNT1139060 and The APC was funded by Manipal Academy of Higher Education. M.N. acknowledges the Manipal Academy of Higher Education, University of New South Wales Collaborative Research Seed Funding and the Department of Science & Technology, India for the SERB start-up research grant (SRG/2019/002130) for financial support. V.A. acknowledges the National Health and Medical Research Council (NHMRC), Australia for an Early Career Fellowship (GNT1139060). N.R. acknowledges T.M.A. Pai Ph.D. Scholarship from the Manipal Academy of Higher Education. The authors also thank the Manipal Institute of Regenerative Medicine, MAHE for the infrastructural support. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = jan,
doi = "10.3390/antiox11010072",
language = "English",
volume = "11",
journal = "Antioxidants",
issn = "2076-3921",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",
}
