TY - JOUR
T1 - Antioxidant potential of Clerodendron viscosum vent. roots
AU - Pankaj, P.
AU - Narayanasamy, V.B.
AU - Manjunatha Setty, M.
AU - Shirwaikar, A.
N1 - Cited By :5
Export Date: 10 November 2017
Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal University, Manipal 576104, India; email: [email protected]
Chemicals/CAS: 1,1 diphenyl 2 picrylhydrazyl, 1898-66-4; alcohol, 64-17-5; ferric ion, 20074-52-6; lipid, 66455-18-3; nitric oxide, 10102-43-9
References: Tiwari, A.K., (2001) Current Sciences, 81, p. 1179; Marx, J.L., Oxygen free radicals linked to many diseases (1987) Science, 235, p. 529; Ajay Arora, S.R.K., Srivastava, G.C., Oxidative stress and antioxidant system in plants (2002) Curr Sci, 82, p. 1227; Geesin, J.G., Gordon, J.S., Berg, R.A., Retinoids affect collagen synthesis through inhibition of ascorbate-induced lipid peroxidation in cultured human dermal fibroblasts (1990) Arch Biochem Biophys, 278, p. 352; Longma, O., (1986) Indian Medicinal Plants, 2, p. 124. , Aryavaidyasala Publications; Jiroveta, L., Buchbauer, G., Puschmann, C., Essential oil analysis of the leaves and root bark of the plant Clerodendrum infortunatum used in Ayurvedic medicine (1999) Herba. Polonica, 45, p. 87; Nadkarni A K., Indian Materia Medica, 13th Edn, Dhootapapeshwar Prakashan, Ltd., Bombay, 1954; 284; Nadkarni, K.M., (1954) Indian Materia Medica, 1, p. 353. , 3rd Edn; Yoganarasimham, S.N., Medicinal plants of India- Tamilnadu 2 (2000), p. 342; Auddy, B., Ferreira, M., Blasina, F., Lafon, L., Arredondo, F., Dajas, F., Tripathi, P.C., Mukherjee, B., Screening of antioxidant activity of three Indian medicinal medicinal plants, traditionally used for the management of neurodegenerative diseases (2003) J Ethanopharmacol, 84, p. 132; Ohkawa, H., Ohishi, N., Yagi, K., Assay for lipid peroxides in animal tissues by thio barbituric acid reaction (1979) Anal Biochem, 95, p. 351; Prashanth Kumar, V., Shashidhara, S., Kumar, M.M., Sridhara, B.Y., Effect of Luffa echinata on lipid peroxidation and free radical scavenging activity (2000) J Pharm Pharmacol, 52, p. 891; Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., Rice Evans, C., Antioxidant activity applying an unproved ABTS radical cation assay (1999) Free Rad Biol Med, 26, p. 1231; Sreejayan, N., Rao, M.N.A., Free radical scavenging activity of curcuminoids (1996) Drug Res, 46, p. 169; Sreejayan, N., Rao, M.N.A., Nitric oxide scavenging by cucuminoids (1997) J Pharm Pharmacol, 49, p. 105; Annie, S., Somashekar, A.P., Antiinflammatory activity and free scavenging studies of Aristolochia bracteolate Lam (2003) Indian J Pharm Sci, 65, p. 68; Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S., Tannenbaum, S.R., Analysis of nitrate and 15N in biological fluids (1982) Anal Biochem, 126, p. 131; Marcocci, L., Maguire, J.J., Droy-Lefaix, M.T., Packer, L., The nitric oxide scavenging property of Ginko biloba extract EGB 761 (1994) Biochem Biophys Res Commun, 201, p. 748; Sanchez-Moreno, C., Methods used to evaluate free radical scavenging activity in foods and biological systems (2002) Food Sci Tech Int, 8, p. 122; Schlesier, K., Harmat, M., Bohm, V., Bitsh, R., (2000) Free radical res, 30, p. 177; Youdim, K.A., Joseph, J.A., A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: A multiplicity of effects (2001) Free Rad Biol Med, 30, p. 583; Gutteridge, J.M.C., Age pigments and free radicals: Fluorescent lipid complexes formed by iron and copper containing proteins (1985) Biochem Biophys Acta, 834, p. 144; Halliwell, B., Superoxide- Dependent formation of hydroxy free radicals in the presence of iron and copper chelates (1978) FEBS Lett, 92, p. 321; Braugghler, J.M., Duncan, C.A., Chase, L.R., The involvement of iron in lipid peroxidation. Importance of ferrous to ferric ratio in initiation (1986) J Biol Chem, 261, p. 10282; Record, I.R., Dreosti, I.E., Mc Inerney, J.K., Changes in plasma antioxidant status following consumption of diets high or low in fruits and vegetables or following dietary supplementation with an antioxidant mixture (2000) Br J Nutr, 85, p. 459; Pryor, W.A., Oxy-radicals and related species, their formation, lifetimes and reactions (1986) Annua Rev Physiol, 48, p. 657; Rice-Evans, C., Miller, N.J., Factors influencing the antioxidant activity determined by the ABTS.+ radical cation assay (1997) Free Rad Res, 26, p. 195; Ialenti, A., Moncada, S., Di Rosa, M., Modulation of adjuvent artritis by endogenous nitric oxide (1993) Br. J Pharmacol, 110, p. 701; Ross, R., The pathogenesis of artherosclerosis: A perspective for the 1990s (1994) Nature, 362, p. 462; Marcocci, L., Packer, L., Droy-Lefaiz, M.T., Sekaki, A., Gardes-Albert, M., Antioxidant action of Ginko biloba extract Egb 761 (1994) Meth Enzymol, 234, p. 462; Blois, M.S., Antioxidant determinations by the use of stable free radical (1958) Nature, 26, p. 1199; Kamalakkannan, N., Mainzen Prince, S., Effect of Aegle marmelos fruit extract on tissue antioxidants in streptozotocin diabetic rats, Indian J Exp Biol (2003), 41, p. 1288. , P; Gibanananda, R., Syed Akhtar, H., Oxidants, antioxidants and carcinogenesis (2002) Indian J Exp Biol, 40, p. 1214
PY - 2007
Y1 - 2007
N2 - The free radical scavenging potential of the roots of C Viscosum was studied by using different antioxidant models of screening. The ethanolic extract at 1000 μg/m1 showed maximum scavenging of the radical cation, 2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonate) (ABTS) observed upto 98.92% followed by scavenging of nitric oxide radical (96.75%), ferric ion radical (94.43% ), 1,1- diphenyl, 2-picryl hydrazyl (DPPH) (92.25%) and antilipid peroxidation potential (81.13%) The aqueous extract showed only moderate activity. The finding justifies the therapeutic application of the plant in the indigenous system of medicine, augmenting its therapeutic value.
AB - The free radical scavenging potential of the roots of C Viscosum was studied by using different antioxidant models of screening. The ethanolic extract at 1000 μg/m1 showed maximum scavenging of the radical cation, 2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonate) (ABTS) observed upto 98.92% followed by scavenging of nitric oxide radical (96.75%), ferric ion radical (94.43% ), 1,1- diphenyl, 2-picryl hydrazyl (DPPH) (92.25%) and antilipid peroxidation potential (81.13%) The aqueous extract showed only moderate activity. The finding justifies the therapeutic application of the plant in the indigenous system of medicine, augmenting its therapeutic value.
M3 - Article
SN - 1827-8620
VL - 2
SP - 226
EP - 235
JO - Pharmacologyonline
JF - Pharmacologyonline
ER -