@article{72f147b4f4074a14a5493b2044ac1811,
title = "Anxiolytic and anticonvulsant activity of aqueous extract of stem bark of Erythrina variegata in rodents",
abstract = "Erythrina variegata and some other species of genus Erythrina are known to act on central nervous system. In India, Erythrina variegata is the species generally used by the traditional practioners of south India for the treatment of mental illness. The anxiolytic effect of aqueous extract (100, 200 and 400 mg/kg) was evaluated by using elevated plus-maze(EPM) model, light-dark transition (LDT) model and open field test (OFT), while Pentylene tetrazole (PTZ), Maximal electroshock (MES) induced convulsions models were used to assess anticonvulsant activity in male swiss albino mice. Pretreatment with aqueous extract and estimation of GABA in rat brain tissues also performed to study the effect of aqueous extract (100, 200 mg/kg) on GABA levels of brain. Aqueous extract showed significant anxiolytic and anticonvulsant activity and also showed significant modulation of GABA levels in cerebellum and also in whole brain other than cerebellum.",
author = "G. Pitchaiah and G.L. Viswanatha and R. Srinath and K. Nandakumar and D. Dayabaran and E.J. Florance",
note = "Cited By :2 Export Date: 10 November 2017 Correspondence Address: Pitchaiah, G.; Department of Pharmacology, PES College of Pharmacy, Bangalore, Karnataka, India Chemicals/CAS: pentetrazole, 54-95-5 References: Atif, A., Farhan, J.A., Krishna, K.P., Divya, V., Amiloride protects against pentylenetetrazole-induced kindling in mice (2005) Br. J. Pharmacol, 145, pp. 880-884; Belzung, C., Griebel, G., Measuring normal and pathological anxiety-like behaviour in mice: A review (2001) Behav. Brain Res, 125 (1-2), pp. 141-149; Bhattacharya, S.K., Satyan, K.S., Experimental methods for evaluation of psychotropic agents in rodents (1997) Indian journal of experimental biology, 35, pp. 565-575; Crawley, J., Goodwin, F.K., Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines (1980) Pharmacology, biochemistry, and behavior, 13, p. 167; Cristiana, M., Murbach, F., Marcia, O.M., Marques, Mirtes, C., Effects of seasonal variation on the central nervous system activity of Ocimum grastissimum L. essential oil (2006) Journal of Ethnopharmacology, 105, pp. 161-166; Emamghoreishi, M., Khasaki, M., Aazam, M.F., Coriander sativum: Evaluation of its anxiolytic effect in the elevated plus-maze (2005) Journal of Ethnopharmacology, 96, pp. 365-370; Hwa, Y.C., Jeong, H.P., Jin, T.H., Hwan, S.Y., Sukjil, S., Bang, Y.H., Anxiolytic-Like Effects of Gensinosides on the Elevated Plus-Maze Model (2005) Biological & pharmaceutical bulletin, 28 (9), pp. 1621-1625; Hogg, S.A., Review of the validity and Variability of the elevated plus-maze as an animal model of anxiety (1996) Pharmacology, biochemistry, and behavior, 54, pp. 21-30; Khandelwal, K.R., (2000) Practical Pharmacognosy-techniques and experiments, pp. 149-155. , Nirali Prakashan, Pune, India, p; Khosla, P., Pandhi, P., Anticonvulsant effect of nimodipine alone and in combination with diazepam on PTZ induced convulsions (2001) Indian Journal of Pharmacology, 33, pp. 208-211; Lister, R.G., The use of a plus maze to measure anxiety in the mouse (1987) Psychopharmacology, 92, pp. 180-185; Madhavan, V., Hemalatha, H.T., Anita, M., Yoganarasimhan, S.N., Antiepileptic activity of alcohol and aqueous extracts of roots and rhizomes of smilax zeylanica linn (2008) Pharmacologyonline, 3, pp. 263-272; Marjan, N.A., Schwann, S.R., Farzaneh, Z., Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: Involvement of benzodiazepine and opioid receptors (2007) BMC complementary and alternative medicine, 7, p. 216; Nadkarni, K.M., 1976. Nadkarni AK (Eds). Indian Meteria Medica.3rd ed. Bombay: Popular Prakashan; Noel, N.W., Joseph, A.A., Helen, O.K., Steven, S.G., Asa, A., Anti-seizure activity of the aqueous leaf extract of Solanum nigrum linn (solanaceae) in experimental animals (2008) African Health Sciences, 8 (2), pp. 74-79; OECD 2001-gudeline on acute oral toxicity (AOT) Environmental health and safety monograph series on testing and adjustment No.425; Rabbani, M., Sajjadi, S.E., Zarei, H.R., Anxiolytic effect of Stachys lavandulifolia Vahl on the elevated plus-maze model of anxiety in mice (2003) Journal of Ethnopharmacology, 89, pp. 271-276; Ribeiro, M.D., Onusic, G.M., Poltronieri1, S.C., Viana, M.B., 2006. Effect of Erythrina velutina and Erythrina mulungu in rats submitted to animal models of anxiety and Depression. Brazilian journal of medical and biological research 39(2), 263-70; Rodgers, R.J., Cao, B.J., Dalvi, A., Hobnes, A., Animal models of anxiety: An ethological perspective (1997) Brazilian journal of medical and biological research, 30, pp. 280-304; Role of GABA in the Pathogenesis and Treatment of anxiety and other neuropsychiatry disorders, , www.vcu-cme.org, Cited on 15th January 2008; Shindikar, A.V., Khan, F., Viswanathan, C.L., Design, synthesis and in vivo anticonvulsant screening in mice of Novel phenylacetamides (2006) European journal of medicinal chemistry, 41, pp. 786-792; Soderphalam, R., Hjorth, S., Engel, J.A., (1989) Pharmacology, biochemistry, and behavior, 32, pp. 259-265; Suher, M.A., Abdullah, S.E., Saleem, S.A., Samir, F.S., Amina, S.A., Effects of acute and chronic Triazolam treatments on brain GABA levels in albino rats (2000) Acta neurobiologiae experimentalis, 60, pp. 447-455; Swinyard, E.A., Brown, W.C., Goodman, L.S., Comparative assays of antiepileptic drugs in mice and rats (1952) Journal of Pharmacological Experiments and Therapeutics, 106, pp. 319-330; Vogel H.G, Vogel WH. (Eds) Drug discovery and Evaluation Pharmacological assays (Springer). 2000; 2: (E) 230-244UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953386724&partnerID=40&md5=b0bc55f2c92ecf10af7d5c2d0ede464c",
year = "2010",
language = "English",
volume = "2",
pages = "40--48",
journal = "International Journal of PharmTech Research",
issn = "0974-4304",
publisher = "Sphinx Knowledge House",
number = "1",
}
