TY - JOUR
T1 - Application of adipose tissue stem cells in regenerative dentistry
T2 - A systematic review
AU - Gaur, Sumit
AU - Agnihotri, Rupali
N1 - Publisher Copyright:
© 2021 Journal of International Society of Preventive and Community Dentistry | Published by Wolters Kluwer - Medknow.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Aim: The aim of this study was to systematically review the applications of adipose tissue stem cells (ADSCs) in regenerative dentistry. Materials and Methods: An electronic search was conducted in Medline (PubMed) and Scopus databases. The original research associated with the role of ADSCs in regeneration of alveolar bone, periodontal ligament (PDL), cementum as well as the dental pulp was evaluated. Among the included studies, three animal studies and one human study had low risk of bias. Results: A total of 33 relevant studies were included in the review. The animal models, in vivo human, and in vitro studies revealed that ADSCs had a significant osteogenic differentiation potential. Besides, they had potential to differentiate into PDL, cementum, and dental pulp tissue. Conclusion: The ADSCs may be specifically applied for bone tissue engineering in the management of alveolar bone defects, specifically in dental implants and periodontal disease. However, their role in regeneration of PDL, cementum, and dental pulp requires further investigations. Overall, their applications in regenerative dentistry needs further verification through human clinical trials.
AB - Aim: The aim of this study was to systematically review the applications of adipose tissue stem cells (ADSCs) in regenerative dentistry. Materials and Methods: An electronic search was conducted in Medline (PubMed) and Scopus databases. The original research associated with the role of ADSCs in regeneration of alveolar bone, periodontal ligament (PDL), cementum as well as the dental pulp was evaluated. Among the included studies, three animal studies and one human study had low risk of bias. Results: A total of 33 relevant studies were included in the review. The animal models, in vivo human, and in vitro studies revealed that ADSCs had a significant osteogenic differentiation potential. Besides, they had potential to differentiate into PDL, cementum, and dental pulp tissue. Conclusion: The ADSCs may be specifically applied for bone tissue engineering in the management of alveolar bone defects, specifically in dental implants and periodontal disease. However, their role in regeneration of PDL, cementum, and dental pulp requires further investigations. Overall, their applications in regenerative dentistry needs further verification through human clinical trials.
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U2 - 10.4103/jispcd.JISPCD_43_21
DO - 10.4103/jispcd.JISPCD_43_21
M3 - Review article
AN - SCOPUS:85108169348
SN - 2231-0762
VL - 11
SP - 266
EP - 271
JO - Journal of International Society of Preventive and Community Dentistry
JF - Journal of International Society of Preventive and Community Dentistry
IS - 3
ER -
