TY - JOUR
T1 - Application of Ugi three component reaction for the synthesis of quinapril hydrochloride
AU - Borase, Bhushan B.
AU - Godbole, Himanshu M.
AU - Singh, Girij P.
AU - Upadhyay, Pritesh R.
AU - Trivedi, Anurag
AU - Bhat, Varadaraj
AU - Shenoy, Gautham G.
N1 - Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.
PY - 2020/1/2
Y1 - 2020/1/2
N2 - A novel, efficient and concise synthesis of chirally pure quinapril hydrochloride is described. The key step is the formation of α-amino amide backbone in one step using Ugi three component reaction. This method allows short access to α-amino amide chain which is a part of many drugs used for treatment of high blood pressure. A large molecular library can be synthesized by changing the components in Ugi reaction.
AB - A novel, efficient and concise synthesis of chirally pure quinapril hydrochloride is described. The key step is the formation of α-amino amide backbone in one step using Ugi three component reaction. This method allows short access to α-amino amide chain which is a part of many drugs used for treatment of high blood pressure. A large molecular library can be synthesized by changing the components in Ugi reaction.
UR - https://www.scopus.com/pages/publications/85075007995
UR - https://www.scopus.com/inward/citedby.url?scp=85075007995&partnerID=8YFLogxK
U2 - 10.1080/00397911.2019.1682168
DO - 10.1080/00397911.2019.1682168
M3 - Article
AN - SCOPUS:85075007995
SN - 0039-7911
VL - 50
SP - 48
EP - 55
JO - Synthetic Communications
JF - Synthetic Communications
IS - 1
ER -