Applications of teriparatide for alveolar bone regeneration: A systematic review

Aim: The aim of this study was to systematically review the applications of teriparatide (TP) for alveolar bone regeneration in oral cavity. Materials and Methods: An electronic search of the data was conducted in Medline (PubMed), Scopus, Web of Science, and Embase. The original research associated with the applications of TP for alveolar bone regeneration was evaluated. Cochrane's tool [for human randomized controlled trials (RCTs)] and SYRCLE's tool (for animal RCTs) were used to assess the risk of bias. About two human and four animal studies had low risk of bias. Results: The results from the 11 studies that were included in the review showed that TP enhanced alveolar bone formation in osteonecrosis of jaws, chronic periodontitis (CP), osseointegration of dental implants as well as orthodontic tooth movement. Conclusion: The TP may be applied for alveolar bone regeneration in osteonecrosis of jaws and CP. However, further human clinical trials are required to verify its applications and adverse effects in various oral bone conditions.