Aptamer-Based Targeting of Nanoplatforms for Cancer Theranostics

Gaurav Tiwari, Ancha Kishore Babu, Charul Khatri, Namdev L. Dhas

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A novel approach to developing solutions for biomedical applications may be made possible by aptamer-functionalized nanoparticles, which combine the benefits of nanoparticles with the cell-targeting properties of aptamers. The focus of the current chapter was on the structure of the aptamer as well as aptamer-conjugated theranostic nanomaterials used to target cancer cells. The systematic development of ligands using exponential enrichment technology produces aptamers, which are single-stranded DNA, RNA, or altered nucleic acid sequences with a high affinity for specific target binding. Aptamer-based nucleic acid nanodevices might effectively assemble on the surfaces of target cells, and an increase in selectivity in the electrochemical and electrochemiluminescence detection of cancer cells has also been brought about by the high specificity of aptamers to target cells. Due to the multivalent effect, aptamer-based inorganic and organic nanomaterials exhibit excellent binding ability of aptamers to target. Target tissues can be completely or partially destroyed by aptamer-bound nanomaterials that show photothermal and photodynamic treatment. Therefore, a novel approach to treating cancer is provided by the combination of nanomaterials and aptamers.

Original languageEnglish
Title of host publicationSite-specific Cancer Nanotheranostics
Subtitle of host publicationA Microenvironment-responsive Approach
PublisherCRC Press/Balkema
Pages225-244
Number of pages20
ISBN (Electronic)9781000960051
ISBN (Print)9781032434827
DOIs
Publication statusPublished - 01-01-2023

All Science Journal Classification (ASJC) codes

  • General Engineering
  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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