TY - JOUR
T1 - Architectured therapeutic and diagnostic nanoplatforms for combating SARS-COV-2
T2 - Role of inorganic, organic, and radioactive materials
AU - Pandey, Abhijeet
AU - Nikam, Ajinkya N.
AU - Mutalik, Sadhana P.
AU - Fernandes, Gasper
AU - Shreya, Ajjappla Basavaraj
AU - Padya, Bharath Singh
AU - Raychaudhuri, Ruchira
AU - Kulkarni, Sanjay
AU - Prassl, Ruth
AU - Subramanian, Suresh
AU - Korde, Aruna
AU - Mutalik, Srinivas
N1 - Funding Information:
The authors are thankful to (i) Manipal Academy of Higher Education (MAHE), Manipal, India (for Postdoctoral Fellowship to Dr Abhijeet Pandey and Dr TMA Pai Doctoral Fellowship to Ajinkya Nikam, Gasper Fernandes and Sanjay Kulkarni), (ii) Science and Engineering Research Board (SERB), Government of India, New Delhi (for Research Fellowship to Shreya AB), Department of Science and Technology (DST), Government of India, New Delhi (for INSPIRE fellowship to Sadhana P Mutalik), Council of Scientific and Industrial Research (CSIR), Government of India, New Delhi (for Junior Research Fellowship to Ruchira Raychaudhuri) and All India Council for Technical Education (AICTE), Government of India, New Delhi (for National Doctoral Fellowship to Bharath S Padya). The authors are also thankful to Manipal College of Pharmaceutical Sciences, MAHE, Manipal, India for providing necessary facilities. Authors are also thankful to Biorender.com , a figure making tool.
Publisher Copyright:
© XXXX American Chemical Society.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/1/11
Y1 - 2021/1/11
N2 - Although extensive research is being done to combat SARS-CoV-2, we are yet far away from a robust conclusion or strategy. With an increased amount of vaccine research, nanotechnology has found its way into vaccine technology. Researchers have explored the use of various nanostructures for delivering the vaccines for enhanced efficacy. Apart from acting as delivery platforms, multiple studies have shown the application of inorganic nanoparticles in suppressing the growth as well as transmission of the virus. The present review gives a detailed description of various inorganic nanomaterials which are being explored for combating SARS-CoV-2 along with their role in suppressing the transmission of the virus either through air or by contact with inanimate surfaces. The review further discusses the use of nanoparticles for development of an antiviral coating that may decrease adhesion of SARS-CoV-2. A separate section has been included describing the role of nanostructures in biosensing and diagnosis of SARS-CoV-2. The role of nanotechnology in providing an alternative therapeutic platform along with the role of radionuclides in SARS-CoV-2 has been described briefly. Based on ongoing research and commercialization of this nanoplatform for a viral disease, the nanomaterials show the potential in therapy, biosensing, and diagnosis of SARS-CoV-2.
AB - Although extensive research is being done to combat SARS-CoV-2, we are yet far away from a robust conclusion or strategy. With an increased amount of vaccine research, nanotechnology has found its way into vaccine technology. Researchers have explored the use of various nanostructures for delivering the vaccines for enhanced efficacy. Apart from acting as delivery platforms, multiple studies have shown the application of inorganic nanoparticles in suppressing the growth as well as transmission of the virus. The present review gives a detailed description of various inorganic nanomaterials which are being explored for combating SARS-CoV-2 along with their role in suppressing the transmission of the virus either through air or by contact with inanimate surfaces. The review further discusses the use of nanoparticles for development of an antiviral coating that may decrease adhesion of SARS-CoV-2. A separate section has been included describing the role of nanostructures in biosensing and diagnosis of SARS-CoV-2. The role of nanotechnology in providing an alternative therapeutic platform along with the role of radionuclides in SARS-CoV-2 has been described briefly. Based on ongoing research and commercialization of this nanoplatform for a viral disease, the nanomaterials show the potential in therapy, biosensing, and diagnosis of SARS-CoV-2.
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U2 - 10.1021/acsbiomaterials.0c01243
DO - 10.1021/acsbiomaterials.0c01243
M3 - Review article
AN - SCOPUS:85099170270
SN - 2373-9878
VL - 7
SP - 31
EP - 54
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
IS - 1
ER -
