Arsenic biotransformations: The cycle of arsenic methylation and demethylation

B. P. Rosen; K. Marapakala; A. A. Ajees; M. Yoshinaga

Arsenic biotransformations: The cycle of arsenic methylation and demethylation

B. P. Rosen
, K. Marapakala
, A. A. Ajees
, M. Yoshinaga

Manipal Institute of Applied Physics (MIAP)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Arsenic is the most prevalent environmental toxic element and causes health problems throughout the world. Here we will describe the connection between arsenic geochemistry and biology, with emphasis on redox and methylation cycles, as well as other arsenic biotransformations. The arsenic methylation cycle remodels the environment, with some members of microbial communities converting inorganic arsenic into organic species, and others breaking down organic arsenicals such as the arsenical herbicide monosodium methylarsenate (MSMA) into inorganic arsenic. The microbes, genes and proteins that carry out these pathways were identified. The enzymes were characterized, and their crystal structure solved. A new enzymatic mechanism for arsenic methylation by human AS3MT that accounts for the production of carcinogenic species is proposed.

Original language	English
Title of host publication	One Century of the Discovery of Arsenicosis in Latin America (1914-2014)
Subtitle of host publication	As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
Publisher	CRC Press/Balkema
Pages	309-311
Number of pages	3
ISBN (Print)	9781138001411
Publication status	Published - 01-01-2014
Event	5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina Duration: 11-05-2014 → 16-05-2014

Publication series

Name	One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment

Conference

Conference	5th International Congress on Arsenic in the Environment, As 2014
Country/Territory	Argentina
City	Buenos Aires
Period	11-05-14 → 16-05-14

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Chemical Health and Safety

Cite this

Rosen, B. P., Marapakala, K., Ajees, A. A., & Yoshinaga, M. (2014). Arsenic biotransformations: The cycle of arsenic methylation and demethylation. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment (pp. 309-311). (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment). CRC Press/Balkema.

Rosen, B. P. ; Marapakala, K. ; Ajees, A. A. et al. / Arsenic biotransformations : The cycle of arsenic methylation and demethylation. One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, 2014. pp. 309-311 (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment).

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title = "Arsenic biotransformations: The cycle of arsenic methylation and demethylation",

abstract = "Arsenic is the most prevalent environmental toxic element and causes health problems throughout the world. Here we will describe the connection between arsenic geochemistry and biology, with emphasis on redox and methylation cycles, as well as other arsenic biotransformations. The arsenic methylation cycle remodels the environment, with some members of microbial communities converting inorganic arsenic into organic species, and others breaking down organic arsenicals such as the arsenical herbicide monosodium methylarsenate (MSMA) into inorganic arsenic. The microbes, genes and proteins that carry out these pathways were identified. The enzymes were characterized, and their crystal structure solved. A new enzymatic mechanism for arsenic methylation by human AS3MT that accounts for the production of carcinogenic species is proposed.",

author = "Rosen, \{B. P.\} and K. Marapakala and Ajees, \{A. A.\} and M. Yoshinaga",

year = "2014",

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isbn = "9781138001411",

series = "One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment",

publisher = "CRC Press/Balkema",

pages = "309--311",

booktitle = "One Century of the Discovery of Arsenicosis in Latin America (1914-2014)",

note = "5th International Congress on Arsenic in the Environment, As 2014 ; Conference date: 11-05-2014 Through 16-05-2014",

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Rosen, BP, Marapakala, K, Ajees, AA & Yoshinaga, M 2014, Arsenic biotransformations: The cycle of arsenic methylation and demethylation. in One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment, CRC Press/Balkema, pp. 309-311, 5th International Congress on Arsenic in the Environment, As 2014, Buenos Aires, Argentina, 11-05-14.

Arsenic biotransformations: The cycle of arsenic methylation and demethylation. / Rosen, B. P.; Marapakala, K.; Ajees, A. A. et al.
One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, 2014. p. 309-311 (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Arsenic biotransformations

T2 - 5th International Congress on Arsenic in the Environment, As 2014

AU - Rosen, B. P.

AU - Marapakala, K.

AU - Ajees, A. A.

AU - Yoshinaga, M.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Arsenic is the most prevalent environmental toxic element and causes health problems throughout the world. Here we will describe the connection between arsenic geochemistry and biology, with emphasis on redox and methylation cycles, as well as other arsenic biotransformations. The arsenic methylation cycle remodels the environment, with some members of microbial communities converting inorganic arsenic into organic species, and others breaking down organic arsenicals such as the arsenical herbicide monosodium methylarsenate (MSMA) into inorganic arsenic. The microbes, genes and proteins that carry out these pathways were identified. The enzymes were characterized, and their crystal structure solved. A new enzymatic mechanism for arsenic methylation by human AS3MT that accounts for the production of carcinogenic species is proposed.

AB - Arsenic is the most prevalent environmental toxic element and causes health problems throughout the world. Here we will describe the connection between arsenic geochemistry and biology, with emphasis on redox and methylation cycles, as well as other arsenic biotransformations. The arsenic methylation cycle remodels the environment, with some members of microbial communities converting inorganic arsenic into organic species, and others breaking down organic arsenicals such as the arsenical herbicide monosodium methylarsenate (MSMA) into inorganic arsenic. The microbes, genes and proteins that carry out these pathways were identified. The enzymes were characterized, and their crystal structure solved. A new enzymatic mechanism for arsenic methylation by human AS3MT that accounts for the production of carcinogenic species is proposed.

UR - https://www.scopus.com/pages/publications/84907366349

UR - https://www.scopus.com/pages/publications/84907366349#tab=citedBy

M3 - Conference contribution

AN - SCOPUS:84907366349

SN - 9781138001411

T3 - One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment

SP - 309

EP - 311

BT - One Century of the Discovery of Arsenicosis in Latin America (1914-2014)

PB - CRC Press/Balkema

Y2 - 11 May 2014 through 16 May 2014

ER -

Rosen BP, Marapakala K, Ajees AA, Yoshinaga M. Arsenic biotransformations: The cycle of arsenic methylation and demethylation. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema. 2014. p. 309-311. (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment).

Arsenic biotransformations: The cycle of arsenic methylation and demethylation

Abstract

Publication series

Conference

UN SDGs

All Science Journal Classification (ASJC) codes

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