Assessing Environmental Safety Risks associated with Ptaquiloside: A Rapidly Leaching Glucoside from Bracken Ferns

S. Narasimhan, S. Bindu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Ptaquiloside (PTA), a glucoside found in common tropical bracken ferns like Pteridium aquilinum, possesses genotoxic and DNA-damaging properties. Its water-solubility makes it susceptible to rapid leaching during rainfall, resulting in its presence in groundwater. PTA's DNA alkylation ability contributes significantly to tumorigenesis, substantiating its carcinogenic potential in animals including humans. Its presence has been confirmed not only in groundwater but also in meat and milk. The unique leaching behavior of PTA, along with evidence of multiple mechanisms leading to cellular mutations, warrants further attention. Research is needed to enhance the isolation and purification of PTA from samples. While the current understanding points to DNA alkylation as the primary mechanism of action, emerging studies suggest potential alternate mechanisms that remain elusive.

Original languageEnglish
Pages (from-to)90-93
Number of pages4
JournalResearch Journal of Chemistry and Environment
Volume28
Issue number3
DOIs
Publication statusPublished - 03-2024

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biochemistry
  • General Chemical Engineering
  • Renewable Energy, Sustainability and the Environment
  • General Environmental Science
  • General Agricultural and Biological Sciences
  • General Earth and Planetary Sciences

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