Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India

Madhurima Mukherjee; Prabin Gyawali; Rajesh Kumar Thakur; Revathi P. Shenoy; Anjali Rao

doi:10.1016/S2222-1808(11)60067-4

Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India

Madhurima Mukherjee
, Prabin Gyawali
, Rajesh Kumar Thakur
, Revathi P. Shenoy
, Anjali Rao^*

^*Corresponding author for this work

Department of Biochemistry, Kasturba Medical College, Manipal

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.

Original language	English
Pages (from-to)	287-288
Number of pages	2
Journal	Asian Pacific Journal of Tropical Disease
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/S2222-1808(11)60067-4
Publication status	Published - 01-12-2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

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10.1016/S2222-1808(11)60067-4

Cite this

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title = "Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India",

abstract = "Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.",

author = "Madhurima Mukherjee and Prabin Gyawali and Thakur, \{Rajesh Kumar\} and Shenoy, \{Revathi P.\} and Anjali Rao",

year = "2011",

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doi = "10.1016/S2222-1808(11)60067-4",

language = "English",

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journal = "Asian Pacific Journal of Tropical Disease",

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Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India. / Mukherjee, Madhurima; Gyawali, Prabin; Thakur, Rajesh Kumar et al.
In: Asian Pacific Journal of Tropical Disease, Vol. 1, No. 4, 01.12.2011, p. 287-288.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India

AU - Mukherjee, Madhurima

AU - Gyawali, Prabin

AU - Thakur, Rajesh Kumar

AU - Shenoy, Revathi P.

AU - Rao, Anjali

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.

AB - Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.

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DO - 10.1016/S2222-1808(11)60067-4

M3 - Article

AN - SCOPUS:82455223703

SN - 2222-1808

VL - 1

SP - 287

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JO - Asian Pacific Journal of Tropical Disease

JF - Asian Pacific Journal of Tropical Disease

IS - 4

ER -

Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India

Abstract

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All Science Journal Classification (ASJC) codes

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