Assessment of perceived realism in AI-generated synthetic spine fracture CT images

BackgroundDeep learning-based decision support systems require synthetic images generated by adversarial networks, which require clinical evaluation to ensure their quality.ObjectiveThe study evaluates perceived realism of high-dimension synthetic spine fracture CT images generated Progressive Growing Generative Adversarial Networks (PGGANs).Method: The study used 2820 spine fracture CT images from 456 patients to train an PGGAN model. The model synthesized images up to 512 × 512 pixels, and the realism of the generated images was assessed using Visual Turing Tests and Fracture Identification Test. Three spine surgeons evaluated the images, and clinical evaluation results were statistically analysed.Result: Spine surgeons have an average prediction accuracy of nearly 50% during clinical evaluations, indicating difficulty in distinguishing between real and generated images. The accuracy varies for different dimensions, with synthetic images being more realistic, especially in 512 × 512-dimension images. During FIT, among 16 generated images of each fracture type, 13-15 images were correctly identified, indicating images are more realistic and clearly depict fracture lines in 512 × 512 dimensions.ConclusionThe study reveals that AI-based PGGAN can generate realistic synthetic spine fracture CT images up to 512 × 512 pixels, making them difficult to distinguish from real images, and improving the automatic spine fracture type detection system.