Association of ABO blood group and rhesus factor with incidence of breast cancer

Breast cancer is one of the leading cause of death. Multifactorial causes play a role in the development of cancer breast which includes endogenous hormonal alteration to familial association and genetic mutations. Association of various blood group antigen is known in gastric, pancreatic, prostate and other cancers. However, in relation to breast cancer, these findings are inconsistent. To study the association of ABO and Rh blood group with incidence of breast carcinoma. Retrospective cases of diagnosed breast cancers over a period of two years, excluding those with familial association and history of oral contraceptive use, were included in the study. Blood group of these patients were retrieved from the hospital data. Control group included healthy female donors of same age group. Data analysis was done using SPSS. Blood group A followed by AB and Rh negative group showed significant association in the study group in the given population.