TY - JOUR
T1 - Astragalus species
T2 - Insights on its chemical composition toward pharmacological applications
AU - Salehi, Bahare
AU - Carneiro, Joara Nályda Pereira
AU - Rocha, Janaína Esmeraldo
AU - Coutinho, Henrique Douglas Melo
AU - Morais Braga, Maria Flaviana Bezerra
AU - Sharifi-Rad, Javad
AU - Semwal, Prabhakar
AU - Painuli, Sakshi
AU - Moujir, Laila Moujir
AU - de Zarate Machado, Victoria
AU - Janakiram, Shriyaa
AU - Anil Kumar, Nanjangud Venkatesh
AU - Martorell, Miquel
AU - Cruz-Martins, Natalia
AU - El Beyrouthy, Marc
AU - Sadaka, Carmen
N1 - Funding Information:
This work was supported by CONICYT PIA/APOYO CCTE AFB170007.
Publisher Copyright:
© 2020 John Wiley & Sons, Ltd.
PY - 2021/5
Y1 - 2021/5
N2 - Astragalus L. is widely distributed throughout the temperate regions of Europe, Asia, and North America. The genus is widely used in folk medicine and in dietary supplements, as well as in cosmetics, teas, coffee, vegetable gums, and as forage for animals. The major phytoconstituents of Astragalus species with beneficial properties are saponins, flavonoids, and polysaccharides. Astragalus extracts and their isolated components exhibited promising in vitro and in vivo biological activities, including antiaging, antiinfective, cytoprotective, antiinflammatory, antioxidant, antitumor, antidiabesity, and immune-enhancing properties. Considering their proven therapeutic potential, the aim of this work is to give a comprehensive summary of the Astragalus spp. and their active components, in an attempt to provide new insight for further clinical development of these xenobiotics. This is the first review that briefly describes their ethnopharmacology, composition, biological, and toxicological properties.
AB - Astragalus L. is widely distributed throughout the temperate regions of Europe, Asia, and North America. The genus is widely used in folk medicine and in dietary supplements, as well as in cosmetics, teas, coffee, vegetable gums, and as forage for animals. The major phytoconstituents of Astragalus species with beneficial properties are saponins, flavonoids, and polysaccharides. Astragalus extracts and their isolated components exhibited promising in vitro and in vivo biological activities, including antiaging, antiinfective, cytoprotective, antiinflammatory, antioxidant, antitumor, antidiabesity, and immune-enhancing properties. Considering their proven therapeutic potential, the aim of this work is to give a comprehensive summary of the Astragalus spp. and their active components, in an attempt to provide new insight for further clinical development of these xenobiotics. This is the first review that briefly describes their ethnopharmacology, composition, biological, and toxicological properties.
UR - https://www.scopus.com/pages/publications/85097624079
UR - https://www.scopus.com/pages/publications/85097624079#tab=citedBy
U2 - 10.1002/ptr.6974
DO - 10.1002/ptr.6974
M3 - Review article
C2 - 33325585
AN - SCOPUS:85097624079
SN - 0951-418X
VL - 35
SP - 2445
EP - 2476
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 5
ER -