TY - JOUR
T1 - Astrocytic MicroRNAs and Transcription Factors in Alzheimer’s Disease and Therapeutic Interventions
AU - Nassar, Ajmal
AU - Kodi, Triveni
AU - Satarker, Sairaj
AU - Chowdari Gurram, Prasada
AU - Upadhya, Dinesh
AU - SM, Fayaz
AU - Mudgal, Jayesh
AU - Nampoothiri, Madhavan
N1 - Funding Information:
The authors acknowledge the Council of Scientific & Industrial Research (CSIR), Government of India, New Delhi, for providing the Senior Research Fellowship to Ajmal Nassar.
Funding Information:
This work was supported by the Council of Scientific & Industrial Research 08/602(0007)2019-EMR-1 and the Manipal Academy of Higher Education.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/12
Y1 - 2022/12
N2 - Astrocytes are important for maintaining cholesterol metabolism, glutamate uptake, and neurotransmission. Indeed, inflammatory processes and neurodegeneration contribute to the altered morphology, gene expression, and function of astrocytes. Astrocytes, in collaboration with numerous microRNAs, regulate brain cholesterol levels as well as glutamatergic and inflammatory signaling, all of which contribute to general brain homeostasis. Neural electrical activity, synaptic plasticity processes, learning, and memory are dependent on the astrocyte–neuron crosstalk. Here, we review the involvement of astrocytic microRNAs that potentially regulate cholesterol metabolism, glutamate uptake, and inflammation in Alzheimer’s disease (AD). The interaction between astrocytic microRNAs and long non-coding RNA and transcription factors specific to astrocytes also contributes to the pathogenesis of AD. Thus, astrocytic microRNAs arise as a promising target, as AD conditions are a worldwide public health problem. This review examines novel therapeutic strategies to target astrocyte dysfunction in AD, such as lipid nanodiscs, engineered G protein-coupled receptors, extracellular vesicles, and nanoparticles.
AB - Astrocytes are important for maintaining cholesterol metabolism, glutamate uptake, and neurotransmission. Indeed, inflammatory processes and neurodegeneration contribute to the altered morphology, gene expression, and function of astrocytes. Astrocytes, in collaboration with numerous microRNAs, regulate brain cholesterol levels as well as glutamatergic and inflammatory signaling, all of which contribute to general brain homeostasis. Neural electrical activity, synaptic plasticity processes, learning, and memory are dependent on the astrocyte–neuron crosstalk. Here, we review the involvement of astrocytic microRNAs that potentially regulate cholesterol metabolism, glutamate uptake, and inflammation in Alzheimer’s disease (AD). The interaction between astrocytic microRNAs and long non-coding RNA and transcription factors specific to astrocytes also contributes to the pathogenesis of AD. Thus, astrocytic microRNAs arise as a promising target, as AD conditions are a worldwide public health problem. This review examines novel therapeutic strategies to target astrocyte dysfunction in AD, such as lipid nanodiscs, engineered G protein-coupled receptors, extracellular vesicles, and nanoparticles.
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U2 - 10.3390/cells11244111
DO - 10.3390/cells11244111
M3 - Review article
AN - SCOPUS:85144877562
SN - 2073-4409
VL - 11
JO - Cells
JF - Cells
IS - 24
M1 - 4111
ER -