TY - JOUR
T1 - Atorvastatin-induced hepatotoxicity, increased by clopidogrel stress on CYP450 Enzyme
T2 - Understanding the mechanism through a case
AU - Thotakura, Sahithi
AU - Singh, Ajit
AU - Khera, Kanav
AU - Chauhan, Sheetal
AU - Devasia, Tom
N1 - Publisher Copyright:
© 2018 Sahithi Thotakura et al.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Statins are widely used drugs for both primary and secondary prevention of various cardiovascular disorders. Cases have been reported on statin-induced hepatitis where the elevation of liver enzymes leads to hepatotoxicity. Here we present a patient with atorvastatin-induced hepatotoxicity and the mechanism accelerated by clopidogrel use. The drugs which are metabolized by CYP450 can increase the risk of hepatitis. CYP4503A4 enzyme metabolizes both atorvastatin and clopidogrel. In this case, clopidogrel has shown the synergistic effect which is responsible for the significant liver injury.
AB - Statins are widely used drugs for both primary and secondary prevention of various cardiovascular disorders. Cases have been reported on statin-induced hepatitis where the elevation of liver enzymes leads to hepatotoxicity. Here we present a patient with atorvastatin-induced hepatotoxicity and the mechanism accelerated by clopidogrel use. The drugs which are metabolized by CYP450 can increase the risk of hepatitis. CYP4503A4 enzyme metabolizes both atorvastatin and clopidogrel. In this case, clopidogrel has shown the synergistic effect which is responsible for the significant liver injury.
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U2 - 10.7324/JAPS.2018.8424
DO - 10.7324/JAPS.2018.8424
M3 - Article
AN - SCOPUS:85046695642
SN - 2231-3354
VL - 8
SP - 168
EP - 170
JO - Journal of Applied Pharmaceutical Science
JF - Journal of Applied Pharmaceutical Science
IS - 4
ER -
