Abstract
Statins are widely used drugs for both primary and secondary prevention of various cardiovascular disorders. Cases have been reported on statin-induced hepatitis where the elevation of liver enzymes leads to hepatotoxicity. Here we present a patient with atorvastatin-induced hepatotoxicity and the mechanism accelerated by clopidogrel use. The drugs which are metabolized by CYP450 can increase the risk of hepatitis. CYP4503A4 enzyme metabolizes both atorvastatin and clopidogrel. In this case, clopidogrel has shown the synergistic effect which is responsible for the significant liver injury.
| Original language | English |
|---|---|
| Pages (from-to) | 168-170 |
| Number of pages | 3 |
| Journal | Journal of Applied Pharmaceutical Science |
| Volume | 8 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 01-04-2018 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- General Pharmacology, Toxicology and Pharmaceutics
- Pharmacology (medical)
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