Attitudes of Algorithms: An Exploration of the Ethics of CRISPR Cas9 through the Lens of ChatGPT

The controversies surrounding CRISPR Cas9 are multifaceted, encompassing concerns related to unintended genetic consequences, ethical and legal considerations in human gene editing, and potential misuse of the technology. Recognizing the influence of Artificial Intelligence in healthcare, this study aims to evaluate the potential of ChatGPT as an educational tool to provide users with information regarding gene editing and its concerns and also, its potential to serve as an ethical decision support system to assist scientists and healthcare providers in analyzing the medical, ethical and legal issues involved in gene editing. ChatGPT 3.5 was used for this evaluation. To assess its potential as an educational tool, 11 open-ended knowledge-based questions delving into various aspects of gene editing were used. Also, to ensure personal beliefs and preferences do not influence the ethical concerns over gene editing, 12 attitude-based questions on a 5-point Likert scale were used. Finally, the interpretation skills of ChatGPT in providing the medical, ethical, and legal considerations were analysed using 4 case scenarios. All answers were analysed independently by the authors and discussed to derive a final grade. In knowledge-based queries, ChatGPT performed well but could enhance accuracy and depth. Attitude-based responses conveyed various stakeholder perspectives on gene editing without offering personal opinions. In interpretation skill analysis, ChatGPT excelled in medical considerations but selectively addressed ethical concerns, omitting some aspects. Legal considerations were lacking, as ChatGPT failed to determine if specific reasons for gene editing align with legal codes or identify the relevant legal bodies for approval. While ChatGPT could be a promising an educational tool and ethical decision support system for CRISPR Cas9, ongoing refinement and development are essential. This will maximize its utility in assisting both the general public and professionals in navigating the complexities of gene editing technology.