TY - CHAP
T1 - Behavioural Phenotyping to Study Cognitive and Non-cognitive Symptoms in the Rodent Model of Alzheimer’s Disease
AU - Shivakumar, Apoorva Bettagere
AU - Mehak, Sonam Fathima
AU - Kumari, Sparsha
AU - Saraf, Vikyath
AU - Gangadharan, Gireesh
N1 - Publisher Copyright:
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Alzheimer’s disease (AD) is a progressive and irreversible neurological disorder that gradually erodes memory and reasoning skills, as well as the ability to perform even simple tasks. Although AD is generally considered a memory disorder, patients with AD shows a range of behavioural and psychological symptoms of dementia (BPSDs) including anxiety, aggression, depression, agitation, apathy, and social dysfunctions. Due to its early impact on the hippocampus and entorhinal cortex, critical brain regions for the memory processing, non-cognitive symptoms associated with AD pathology are frequently overlooked. Animal models are indispensable tools for AD research and have been extensively used to represent the cognitive deficits caused by AD pathology. We are discussing here the most commonly used behavioural tests to detect cognitive and non-cognitive symptoms of AD in rodent models.
AB - Alzheimer’s disease (AD) is a progressive and irreversible neurological disorder that gradually erodes memory and reasoning skills, as well as the ability to perform even simple tasks. Although AD is generally considered a memory disorder, patients with AD shows a range of behavioural and psychological symptoms of dementia (BPSDs) including anxiety, aggression, depression, agitation, apathy, and social dysfunctions. Due to its early impact on the hippocampus and entorhinal cortex, critical brain regions for the memory processing, non-cognitive symptoms associated with AD pathology are frequently overlooked. Animal models are indispensable tools for AD research and have been extensively used to represent the cognitive deficits caused by AD pathology. We are discussing here the most commonly used behavioural tests to detect cognitive and non-cognitive symptoms of AD in rodent models.
UR - https://www.scopus.com/pages/publications/85160147788
UR - https://www.scopus.com/pages/publications/85160147788#tab=citedBy
U2 - 10.1007/978-981-19-1352-5_14
DO - 10.1007/978-981-19-1352-5_14
M3 - Chapter
AN - SCOPUS:85160147788
SN - 9789811913518
SP - 243
EP - 257
BT - Advances in Brain Imaging Techniques
PB - Springer Nature
ER -