Abstract
Objectives: The present study evaluated the beneficial effects of omega 3 PUFA present in fish oil on neurosensorial impairments, namely learning, memory and anxiety in Streptozotocin (STZ) induced diabetic rats. The brain homogenate was analysed for oxidative status following Omega 3 PUFA treatment.
Methods: Male, Wistar rats of 2-3 months old were divided into non diabetic controls, diabetic control, & fish oil treated diabetic rats (n=6). Diabetes was induced by injection of STZ (48 mg/kg, ip). Animals were treated orally for 30 days with a dose in each group of 0.5 g/kg/day of fish oil. All experiments were conducted after ethical committee clearance was obtained.
Results: Memory and exploratory behavior were improved (p<0.01) in fish oil treated rats as compared with diabetic rats. A significant (p<0.001) decrease in MDA and a significant increase (p<0.001) in total antioxidant level (TAO) were observed in fish oil treated rats.
Conclusion : Omega 3 PUFA present in fish oil could be used an adjuvant therapy for treatment and prevention of neurosensorial impairment in diabetes mellitus.
| Original language | English |
|---|---|
| Pages (from-to) | 346-353 |
| Number of pages | 8 |
| Journal | Indian Journal of Physiology and Pharmacology |
| Volume | 58 |
| Issue number | 4 |
| Publication status | Published - 01-10-2014 |
All Science Journal Classification (ASJC) codes
- Physiology
- Pharmacology
- Physiology (medical)
