Bilateral blindness due to anti-tubercular treatment: A rare presentation

Sulatha V. Bhandary; Akshay Sehgal; Lavanya G. Rao; A. Krishna Rao; Pallak Kusumgar; Harish Thanusubramanian

doi:10.22159/ajpcr.2016.v9s2.11823

Bilateral blindness due to anti-tubercular treatment: A rare presentation

Sulatha V. Bhandary, Akshay Sehgal^*, Lavanya G. Rao, A. Krishna Rao, Pallak Kusumgar, Harish Thanusubramanian

^*Corresponding author for this work

Department of Ophthalmology, Kasturba Medical College, Manipal

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Ethambutol and isoniazid (INH) are antimicrobial agents used in the treatment of tuberculosis. Optic neuropathy is a well-recognized toxic effect of these drugs, usually manifesting as a decrease in visual acuity and deficits in color vision. This study presents the case of a 75-year-old male diagnosed of spinal tuberculosis, who developed irreversible bilateral optic neuropathy causing complete blindness induced by ethambutol and INH. Ophthalmologic examination revealed sluggish pupillary reactions and optic disc pallor in both eyes. Visual evoked potential and magnetic resonance imaging brain complemented the confirmation of the diagnosis.

Original language	English
Pages (from-to)	1-2
Number of pages	2
Journal	Asian Journal of Pharmaceutical and Clinical Research
Volume	9
DOIs	https://doi.org/10.22159/ajpcr.2016.v9s2.11823
Publication status	Published - 01-10-2016

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science
Pharmacology (medical)

UN SDGs

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10.22159/ajpcr.2016.v9s2.11823

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title = "Bilateral blindness due to anti-tubercular treatment: A rare presentation",

abstract = "Ethambutol and isoniazid (INH) are antimicrobial agents used in the treatment of tuberculosis. Optic neuropathy is a well-recognized toxic effect of these drugs, usually manifesting as a decrease in visual acuity and deficits in color vision. This study presents the case of a 75-year-old male diagnosed of spinal tuberculosis, who developed irreversible bilateral optic neuropathy causing complete blindness induced by ethambutol and INH. Ophthalmologic examination revealed sluggish pupillary reactions and optic disc pallor in both eyes. Visual evoked potential and magnetic resonance imaging brain complemented the confirmation of the diagnosis.",

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AU - Bhandary, Sulatha V.

AU - Sehgal, Akshay

AU - Rao, Lavanya G.

AU - Krishna Rao, A.

AU - Kusumgar, Pallak

AU - Thanusubramanian, Harish

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AB - Ethambutol and isoniazid (INH) are antimicrobial agents used in the treatment of tuberculosis. Optic neuropathy is a well-recognized toxic effect of these drugs, usually manifesting as a decrease in visual acuity and deficits in color vision. This study presents the case of a 75-year-old male diagnosed of spinal tuberculosis, who developed irreversible bilateral optic neuropathy causing complete blindness induced by ethambutol and INH. Ophthalmologic examination revealed sluggish pupillary reactions and optic disc pallor in both eyes. Visual evoked potential and magnetic resonance imaging brain complemented the confirmation of the diagnosis.

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Bilateral blindness due to anti-tubercular treatment: A rare presentation

Abstract

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