@article{2fdd244b9f6440f6ad9efa26f4860f9a,
title = "Bioactive caffeic acid esters from Glycyrrhiza glabra",
abstract = "Thin layer chromatography bioautography (using DPPH spray reagent) guided fractionation of Glycyrrhiza glabra led to the isolation of two caffeic acid derivative esters, viz. eicosanyl caffeate (1) and docosyl caffeate (2). The two compounds exhibited potent elastase inhibitory activity, with IC50 values of 0.99μg mL-1 and 1.4μg mL-1 for 1 and 2, respectively. The compounds also showed moderate antioxidant activity in DPPH and ABTS scavenging assays. The results indicate a possible role of caffeic acid derivatives, in addition to flavonoids in the anti-ulcer properties of G. glabra.",
author = "S. Dey and M. Deepak and M. Setty and P. D'Souza and A. Agarwal and G.K. Sangli",
note = "Cited By :11 Export Date: 10 November 2017 CODEN: NPRAA Correspondence Address: Deepak, M.; RD Centre, Natural Remedies Pvt. Ltd., Bangalore, India; email: deepak@naturalremedy.com Chemicals/CAS: 1,1 diphenyl 2 picrylhydrazyl, 1898-66-4; 2,2' azinobis(3 ethylbenzothiazoline 6 sulfonic acid), 28752-68-3; acetic acid, 127-08-2, 127-09-3, 64-19-7, 71-50-1; gallic acid, 149-91-7; methanol, 67-56-1; ursolic acid, 77-52-1; water, 7732-18-5; Antioxidants; Caffeic Acids; Enzyme Inhibitors; Esters; Pancreatic Elastase, 3.4.21.36; Plant Extracts; caffeic acid, 331-39-5 References: Auddy, B., Ferreira, M., Blasina, F., Lafon, L., Arredondo, F., Dajas, F., Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegenerative diseases (2003) Journal of Ethnopharmacology, 84, pp. 131-138; Bafna, P.A., Balaraman, R., Anti-ulcer and anti-oxidant activity of pepticare, a herbomineral formulation (2005) Phytomedicine, 12, pp. 264-270; Beith, J., Spiess, B., Wermuth, C.G., The synthesis and analytical use of a highly sensitive and convenient substrate of elastase (1974) Biochemical Medicine, 11, pp. 350-357; Belinky, P.A., Aviram, M., Fuhrman, B., Rosenbat, M., Vaya, J., The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation (1998) Atherosclerosis, 137, pp. 49-61; Borrelli, F., Izzo, A.A., The plant kingdom as a source of anti-ulcer remedies (2000) Phytotherapy Research, 14, pp. 581-591; Fukai, T., Satoh, K., Nomura, T., Sakagami, H., Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra (2003) Fitoterapia, 74, pp. 624-629; Fukai, T., Satoh, K., Nomura, T., Sakagami, H., Antinephritis and radical scavenging activity of prenylflavonoids (2003) Fitoterapia, 74, pp. 720-724; Gibbons, S., Mathew, K.T., Gray, A.I., A caffeic acid ester from Halocnemum strobilaceum (1999) Phytochemistry, 51, pp. 465-467; Haraguchi, H., Yoshida, N., Ishikawa, H., Tamura, Y., Mizutani, K., Kinoshita, T., Protection of mitochondrial functions against oxidative stresses by isoflavans from Glycyrrhiza glabra (2000) Journal of Pharmacy and Pharmacology, 52, pp. 219-223; Kang, S.S., Kim, C.M., Korean indigenous plants. Part 2. Isolation of 1-eicosanyl caffeate from Echinosphora koreensis (1987) Archives of Pharmacal Research, 10, pp. 67-68; Kisiel, W., Jakupowic, J., Long chain alkyl hydroxy cinnamates from Crepis taraxacifolia (1995) Planta Medica, 61, pp. 87-88; Liu, W., Okajima, K., Murakami, K., Harada, N., Isobe, H., Irie, T., Role of neutrophil elastase in stress-induced gastric mucosal injury in rats (1998) Journal of Laboratory and Clinical Medicine, 132 (5), pp. 432-439; Okada, K., Tamura, Y., Yamamoto, M., Inou, Y., Takagaki, R., Takahashi, K., Identification of antimicrobial and anti-oxidant constituents from licorice of Russian and Xinjiang origin (1989) Chemical & Pharmaceutical Bulletin, 37, pp. 2528-2530; Repetto, M.G., Llesny Braz, S.F., Antioxidant properties of natural compounds used in popular medicine for gastric ulcers (2002) Journal of Medical and Biological Research, 35, pp. 523-534; Vani, T., Rajini, M., Sarkar, S., Shishoo, C.J., Antioxidant properties of the Ayurvedic formulation - Triphala and its constituents (1997) International Journal of Clinical Pharmacology Research, 35, pp. 313-317; Vaya, J., Belinky, P.A., Aviram, M., Antioxidant constituents from licorice roots: Isolation, structure elucidation and antioxidative capacity towards LDL oxidation (1997) Free Radicals in Biology & Medicine, 23, pp. 302-313",
year = "2009",
doi = "10.1080/14786410802134348",
language = "English",
volume = "23",
pages = "1657--1663",
journal = "Natural Product Research",
issn = "1478-6419",
publisher = "Taylor and Francis Ltd.",
number = "18",
}