TY - JOUR
T1 - Bioactive PLGA–curcumin microparticle-embedded chitosan scaffold
T2 - in vitro and in vivo evaluation
AU - Amirthalingam, Muthukumar
AU - Kasinathan, Narayanan
AU - Amuthan, Arul
AU - Mutalik, Srinivas
AU - Sreenivasa Reddy, M.
AU - Nayanabhirama, Udupa
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/2/17
Y1 - 2017/2/17
N2 - Wound healing is a complex process affected by several factors. In the present work, novel biocompatible PLGA–curcumin microparticle-embedded chitosan scaffold was fabricated for wound-healing application. Process variables involved in the preparation of microparticles were optimized using design of experiment. Scanning electron microscopy (SEM) confirmed the porous nature of scaffold with embedded microparticles. A maximum release of 14% of the encapsulated curcumin was observed at 12th hour. Modified tube dilution method showed that scaffold significantly (p < 0.05) reduced multiplication of Staphylococcus aureus. More than 50% of the excised wound in rats healed in 4 days with an epithilization period of 18 days.
AB - Wound healing is a complex process affected by several factors. In the present work, novel biocompatible PLGA–curcumin microparticle-embedded chitosan scaffold was fabricated for wound-healing application. Process variables involved in the preparation of microparticles were optimized using design of experiment. Scanning electron microscopy (SEM) confirmed the porous nature of scaffold with embedded microparticles. A maximum release of 14% of the encapsulated curcumin was observed at 12th hour. Modified tube dilution method showed that scaffold significantly (p < 0.05) reduced multiplication of Staphylococcus aureus. More than 50% of the excised wound in rats healed in 4 days with an epithilization period of 18 days.
UR - http://www.scopus.com/inward/record.url?scp=85010434998&partnerID=8YFLogxK
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U2 - 10.3109/21691401.2016.1146727
DO - 10.3109/21691401.2016.1146727
M3 - Article
C2 - 26912183
AN - SCOPUS:85010434998
SN - 2169-1401
VL - 45
SP - 233
EP - 241
JO - Artificial Cells, Nanomedicine and Biotechnology
JF - Artificial Cells, Nanomedicine and Biotechnology
IS - 2
ER -