TY - JOUR
T1 - Biocompatible graphitic carbon nitride based fluorescent probe for imaging of breast cancer cell
AU - Talukdar, Meenakshi
AU - Kuthethur, Raviprasad
AU - Banik, Soumyabrata
AU - Mazumder, Nirmal
AU - Chakrabarty, Sanjiban
AU - Deb, Pritam
N1 - Funding Information:
M.T. acknowledges Tezpur University for financial support as Institute Research Fellow. Moreover, M.T. would like to thank CSIR, Govt. of India for SRF funding. This work was supported by N-BIOS award project, Department of Biotechnology, Government of India; vide grant no. 102/IFD/SAN/5142/2018-19. Also, the authors acknowledge DST-FIST project of Dept. of Physics, Tezpur University.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/2/15
Y1 - 2023/2/15
N2 - Fluorescence imaging materials have gained recent attention compared to existing organic compounds, which have limited lifetime and low stability in biological environments. In this work, a superparamagnetic g-C3N4@FeNi3 heterostructure is developed for sensitive and early cancer detection, showing its potential for fluorescence imaging guidance and monitoring the targeted cancerous cells. Apart from superparamagnetic behaviour, biocompatibility of g-C3N4@FeNi3 heterostructure was evaluated in Human Embryonic Kidney cell line (HEK293) and human breast cancer cell line (MCF-7) which showed no significant change in their viability from 10 µM to 500 µM concentration. Further, confocal fluorescence microscopy in living cancer cells confirmed the potential of this heterostructure in overcoming the drawbacks of commercial fluorophores and their merit of application as labels for optical imaging.
AB - Fluorescence imaging materials have gained recent attention compared to existing organic compounds, which have limited lifetime and low stability in biological environments. In this work, a superparamagnetic g-C3N4@FeNi3 heterostructure is developed for sensitive and early cancer detection, showing its potential for fluorescence imaging guidance and monitoring the targeted cancerous cells. Apart from superparamagnetic behaviour, biocompatibility of g-C3N4@FeNi3 heterostructure was evaluated in Human Embryonic Kidney cell line (HEK293) and human breast cancer cell line (MCF-7) which showed no significant change in their viability from 10 µM to 500 µM concentration. Further, confocal fluorescence microscopy in living cancer cells confirmed the potential of this heterostructure in overcoming the drawbacks of commercial fluorophores and their merit of application as labels for optical imaging.
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U2 - 10.1016/j.matlet.2022.133674
DO - 10.1016/j.matlet.2022.133674
M3 - Article
AN - SCOPUS:85143732666
SN - 0167-577X
VL - 333
JO - Materials Letters
JF - Materials Letters
M1 - 133674
ER -
