TY - JOUR
T1 - Bioderived cellulose fibre-guar gum grafted poly (N, N′-dimethylacrylamide) polymer network for controlled release of metformin hydrochloride
AU - Rai, Smitha
AU - Raychaudhuri, Ruchira
AU - Kudarha, Ritu
AU - Mutalik, Srinivas
AU - Vishalakshi, B.
AU - Usha, K. M.
N1 - Funding Information:
The authors are grateful to the DST-PURSE Instrumentation Centre, Mangalore University, Mangalagangothri, Karnataka for carrying out FESEM, TGA and UV–Vis spectral analysis. The authors thank Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal for providing the research facilities. The authors are thankful to i) Council of Scientific and Industrial Research (CSIR), Government of India, New Delhi for Senior Research Fellowship to Ruchira Raychaudhuri and ii) DST (Department of Science and Technology), Government of India, New Delhi for providing Senior Research Fellowship to Ritu Kudarha.
Publisher Copyright:
© 2023
PY - 2023/12/31
Y1 - 2023/12/31
N2 - An interpenetrating polymer network (IPN) of areca cellulose and guar gum grafted with poly (N, N′-dimethylacrylamide) was made by microwave irradiation technique. N, N-methylenebisacrylamide (MBA) was used as the crosslinking agent. The network polymer was characterised using Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Powder X-ray Diffraction (XRD) and Field Emission Scanning Electron Microscopy (FESEM). The chemical interaction between the drug and the polymer was studied using Differential Scanning Calorimetry (DSC). The swelling of the gel was measured under different pH conditions and the swelling parameters were evaluated. The gel was loaded with an anti-diabetic drug, Metformin Hydrochloride, and the in vitro drug release was studied in gastric and intestinal conditions. The results indicated complete release of the drug in 6 h under pH 1.2 and in 10 h under pH 7.4. The kinetic analysis of release data indicated the drug release to follow Higuchi's model. The release exponent “n” of Korsmeyer-Peppas model was found to be >0.45 indicating the drug diffusion to be a non-Fickian process.
AB - An interpenetrating polymer network (IPN) of areca cellulose and guar gum grafted with poly (N, N′-dimethylacrylamide) was made by microwave irradiation technique. N, N-methylenebisacrylamide (MBA) was used as the crosslinking agent. The network polymer was characterised using Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Powder X-ray Diffraction (XRD) and Field Emission Scanning Electron Microscopy (FESEM). The chemical interaction between the drug and the polymer was studied using Differential Scanning Calorimetry (DSC). The swelling of the gel was measured under different pH conditions and the swelling parameters were evaluated. The gel was loaded with an anti-diabetic drug, Metformin Hydrochloride, and the in vitro drug release was studied in gastric and intestinal conditions. The results indicated complete release of the drug in 6 h under pH 1.2 and in 10 h under pH 7.4. The kinetic analysis of release data indicated the drug release to follow Higuchi's model. The release exponent “n” of Korsmeyer-Peppas model was found to be >0.45 indicating the drug diffusion to be a non-Fickian process.
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U2 - 10.1016/j.ijbiomac.2023.126882
DO - 10.1016/j.ijbiomac.2023.126882
M3 - Article
C2 - 37717871
AN - SCOPUS:85171988724
SN - 0141-8130
VL - 253
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
M1 - 126882
ER -
