Bioderived cellulose fibre-guar gum grafted poly (N, N′-dimethylacrylamide) polymer network for controlled release of metformin hydrochloride

An interpenetrating polymer network (IPN) of areca cellulose and guar gum grafted with poly (N, N′-dimethylacrylamide) was made by microwave irradiation technique. N, N-methylenebisacrylamide (MBA) was used as the crosslinking agent. The network polymer was characterised using Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Powder X-ray Diffraction (XRD) and Field Emission Scanning Electron Microscopy (FESEM). The chemical interaction between the drug and the polymer was studied using Differential Scanning Calorimetry (DSC). The swelling of the gel was measured under different pH conditions and the swelling parameters were evaluated. The gel was loaded with an anti-diabetic drug, Metformin Hydrochloride, and the in vitro drug release was studied in gastric and intestinal conditions. The results indicated complete release of the drug in 6 h under pH 1.2 and in 10 h under pH 7.4. The kinetic analysis of release data indicated the drug release to follow Higuchi's model. The release exponent “n” of Korsmeyer-Peppas model was found to be >0.45 indicating the drug diffusion to be a non-Fickian process.