Biosubstitutes for dural closure: Unveiling research, application, and future prospects of dura mater alternatives

Dolphee Khurana, Ankitha Suresh, Raghavendra Nayak, Manjunath Shetty, Rohit Kumar Sarda, Jonathan C. Knowles, Hae Won Kim, Rajendra K. Singh, Bhisham Narayan Singh

Research output: Contribution to journalReview articlepeer-review

Abstract

The dura mater, as the crucial outermost protective layer of the meninges, plays a vital role in safeguarding the underlying brain tissue. Neurosurgeons face significant challenges in dealing with trauma or large defects in the dura mater, as they must address the potential complications, such as wound infections, pseudomeningocele formation, cerebrospinal fluid leakage, and cerebral herniation. Therefore, the development of dural substitutes for repairing or reconstructing the damaged dura mater holds clinical significance. In this review we highlight the progress in the development of dural substitutes, encompassing autologous, allogeneic, and xenogeneic replacements, as well as the polymeric-based dural substitutes fabricated through various scaffolding techniques. In particular, we explore the development of composite materials that exhibit improved physical and biological properties for advanced dural substitutes. Furthermore, we address the challenges and prospects associated with developing clinically relevant alternatives to the dura mater.

Original languageEnglish
JournalJournal of Tissue Engineering
Volume15
DOIs
Publication statusPublished - 01-01-2024

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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