@inproceedings{206d77eba83d4e3a82c2fe1327a74269,
title = "Blood glucose control in type I diabetics: An output feedback approach",
abstract = "A robust H∞ controller was developed to deliver insulin via a mechanical pump in Type I diabetic patients. A fundamental nonlinear diabetic patient model was linearized and then reduced to a third-order linear form for controller synthesis. H∞ control was applied for the insulin delivery to prevent the hyperglycemic levels in Type I diabetic patient. Uncertainty in the nonlinear model was characterized by up to ±40% variation in eight physiological parameters. A sensitivity analysis identified the three parameter set having the most significant effect on glucose and insulin dynamics over the frequency range of interest [0.02 0.2](rad/min). This uncertainty was represented in the frequency domain and incorporated in the controller design. The controller performance was assessed in terms of its ability to track a normoglycemic set point(81.1 mg/dL) in response to a 50 g meal disturbance. In the nominal continuous-time case, controller maintained glucose concentrations within ± 3.3 mg/dL of set point. A controller tuned to accommodate uncertainty yielded a maximum deviation of 17.6 mg/dL for the worst-case parameter variation.",
author = "Surekha Kamath and George, {V. I.} and S. Vidyasagar",
year = "2008",
doi = "10.1007/978-3-540-69139-6-165",
language = "English",
isbn = "9783540691389",
volume = "21 IFMBE",
series = "IFMBE Proceedings",
publisher = "Springer Verlag",
number = "1",
pages = "661--664",
booktitle = "4th Kuala Lumpur International Conference on Biomedical Engineering 2008, Biomed 2008",
address = "Germany",
edition = "1",
note = "4th Kuala Lumpur International Conference on Biomedical Engineering 2008, Biomed 2008 ; Conference date: 25-06-2008 Through 28-06-2008",
}