Bortezomib induced subconjunctival hemorrhage

Navin Patil; Ommurugan Balaji; Karthik S. Udupa; Karthik Rao

doi:10.22159/ajpcr.2017.v10i4.16907

Bortezomib induced subconjunctival hemorrhage

Navin Patil, Ommurugan Balaji, Karthik S. Udupa, Karthik Rao

Research output: Contribution to journal › Article › peer-review

Abstract

Many drugs are used in the treatment of multiple myeloma but thalidomide, lenalidomide, bortezomib, and dexamethasone and their combination remain the main stay of treatment. The molecular formula of bortezomib is C₁₉H₂₅BN₄O₄ and its chemical name is (3-methyl-1-(3-phenyl-2-pyrazin-2-ylcarbonylamino-propanoyl) amino-butyl) boronic acid. Mechanisms by which it acts is usually by 26 SProteasome inhibition leading to degradation of anti-apoptotic proteins. Bortezomib is known to cause many side effects. Hence, we report a rare case of bortezomib-induced subconjunctival hemorrhage in our tertiary care hospital.

Original language	English
Pages (from-to)	10-11
Number of pages	2
Journal	Asian Journal of Pharmaceutical and Clinical Research
Volume	10
Issue number	4
DOIs	https://doi.org/10.22159/ajpcr.2017.v10i4.16907
Publication status	Published - 01-04-2017

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science
Pharmacology (medical)

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title = "Bortezomib induced subconjunctival hemorrhage",

abstract = "Many drugs are used in the treatment of multiple myeloma but thalidomide, lenalidomide, bortezomib, and dexamethasone and their combination remain the main stay of treatment. The molecular formula of bortezomib is C19H25BN4O4 and its chemical name is (3-methyl-1-(3-phenyl-2-pyrazin-2-ylcarbonylamino-propanoyl) amino-butyl) boronic acid. Mechanisms by which it acts is usually by 26 SProteasome inhibition leading to degradation of anti-apoptotic proteins. Bortezomib is known to cause many side effects. Hence, we report a rare case of bortezomib-induced subconjunctival hemorrhage in our tertiary care hospital.",

author = "Navin Patil and Ommurugan Balaji and Udupa, {Karthik S.} and Karthik Rao",

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T1 - Bortezomib induced subconjunctival hemorrhage

AU - Patil, Navin

AU - Balaji, Ommurugan

AU - Udupa, Karthik S.

AU - Rao, Karthik

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Many drugs are used in the treatment of multiple myeloma but thalidomide, lenalidomide, bortezomib, and dexamethasone and their combination remain the main stay of treatment. The molecular formula of bortezomib is C19H25BN4O4 and its chemical name is (3-methyl-1-(3-phenyl-2-pyrazin-2-ylcarbonylamino-propanoyl) amino-butyl) boronic acid. Mechanisms by which it acts is usually by 26 SProteasome inhibition leading to degradation of anti-apoptotic proteins. Bortezomib is known to cause many side effects. Hence, we report a rare case of bortezomib-induced subconjunctival hemorrhage in our tertiary care hospital.

AB - Many drugs are used in the treatment of multiple myeloma but thalidomide, lenalidomide, bortezomib, and dexamethasone and their combination remain the main stay of treatment. The molecular formula of bortezomib is C19H25BN4O4 and its chemical name is (3-methyl-1-(3-phenyl-2-pyrazin-2-ylcarbonylamino-propanoyl) amino-butyl) boronic acid. Mechanisms by which it acts is usually by 26 SProteasome inhibition leading to degradation of anti-apoptotic proteins. Bortezomib is known to cause many side effects. Hence, we report a rare case of bortezomib-induced subconjunctival hemorrhage in our tertiary care hospital.

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Bortezomib induced subconjunctival hemorrhage

Abstract

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